WDR5B Antibody (E-6): sc-515077
- WDR5B Antibody (E-6) is a mouse monoclonal IgG2a κ WDR5B antibody provided at 200 µg/ml
- raised against amino acids 271-324 mapping near the C-terminus of WDR5B of human origin
- WDR5B Antibody (E-6) is recommended for detection of WDR5B of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-WDR5B Antibody (E-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for WDR5B Antibody (E-6) for WB applications. This reagent is now offered in a bundle with WDR5B Antibody (E-6) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
WDR5B Antibody (E-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects WDR5B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-WDR5B antibody (E-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. WDR5B protein consists of 330 amino acids and serves as a probable substrate receptor subunit of a CUL-RING E3 protein ligase complex, playing a crucial role in regulating protein degradation and cellular signaling pathways. WDR5B protein interacts with CUL-4B and DDB1, essential components of the ubiquitin-proteasome system, thereby influencing various cellular processes such as DNA repair, cell cycle regulation, and gene expression. Seven WD repeats in WDR5B are significant as these structural motifs are often involved in protein-protein interactions, facilitating the assembly of multiprotein complexes vital for cellular function. WDR5B is encoded by a gene located on human chromosome 3, a region associated with several genetic diseases and cancer-related loci, highlighting WDR5B protein′s importance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
WDR5B Antibody (E-6) References:
- Molecular cytogenetic dissection of human chromosomes 3 and 21 evolution. | Müller, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 206-11. PMID: 10618396
- [New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification]. | Braga, EA., et al. 2003. Mol Biol (Mosk). 37: 194-211. PMID: 12723467
- Plasticity of human chromosome 3 during primate evolution. | Tsend-Ayush, E., et al. 2004. Genomics. 83: 193-202. PMID: 14706448
- Genomic structure and paralogous regions of the inversion breakpoint occurring between human chromosome 3p12.3 and orangutan chromosome 2. | Yue, Y., et al. 2005. Cytogenet Genome Res. 108: 98-105. PMID: 15545721
- Comparative cytogenetics of human chromosome 3q21.3 reveals a hot spot for ectopic recombination in hominoid evolution. | Yue, Y., et al. 2005. Genomics. 85: 36-47. PMID: 15607420
- Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the 'elimination test'. | Darai, E., et al. 2005. Genomics. 86: 1-12. PMID: 15913951
- The DNA sequence, annotation and analysis of human chromosome 3. | Muzny, DM., et al. 2006. Nature. 440: 1194-8. PMID: 16641997
- Establishment and characterization of two uveal melanoma cell lines derived from tumors with loss of one chromosome 3. | Nareyeck, G., et al. 2006. Exp Eye Res. 83: 858-64. PMID: 16750193
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WDR5B Antibody (E-6) | sc-515077 | 200 µg/ml | $322.00 | |||
WDR5B Antibody (E-6): m-IgGκ BP-HRP Bundle | sc-524928 | 200 µg Ab, 40 µg BP | $361.00 | |||
WDR5B Antibody (E-6) AC | sc-515077 AC | 500 µg/ml, 25% agarose | $424.00 | |||
WDR5B Antibody (E-6) HRP | sc-515077 HRP | 200 µg/ml | $322.00 | |||
WDR5B Antibody (E-6) FITC | sc-515077 FITC | 200 µg/ml | $336.00 | |||
WDR5B Antibody (E-6) PE | sc-515077 PE | 200 µg/ml | $349.00 | |||
WDR5B Antibody (E-6) Alexa Fluor® 488 | sc-515077 AF488 | 200 µg/ml | $364.00 | |||
WDR5B Antibody (E-6) Alexa Fluor® 546 | sc-515077 AF546 | 200 µg/ml | $364.00 | |||
WDR5B Antibody (E-6) Alexa Fluor® 594 | sc-515077 AF594 | 200 µg/ml | $364.00 | |||
WDR5B Antibody (E-6) Alexa Fluor® 647 | sc-515077 AF647 | 200 µg/ml | $364.00 | |||
WDR5B Antibody (E-6) Alexa Fluor® 680 | sc-515077 AF680 | 200 µg/ml | $364.00 | |||
WDR5B Antibody (E-6) Alexa Fluor® 790 | sc-515077 AF790 | 200 µg/ml | $364.00 |