WBSCR11 Antibody (GTF5I102): sc-81425

WBSCR11 Antibody (GTF5I102) is a mouse monoclonal IgG1 antibody that detects WBSCR11 protein of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-WBSCR11 antibody (GTF5I102) is available as the non-conjugated format. The WBSCR11 gene, located within the critical deletion region associated with Williams-Beuren syndrome (WBS), encodes a transcription factor that plays a crucial role in regulating gene expression during development. WBSCR11 is essential for proper cellular function, interacting with various transcriptional machinery proteins to facilitate target gene transcription vital for normal growth and development. Loss of WBSCR11 due to hemizygous microdeletion on chromosome 7q11.23 contributes to developmental symptoms in WBS, including cognitive impairments and distinctive physical traits. WBSCR11 shows expression in all adult tissues and specific patterns during embryogenesis, highlighting developmental importance. WBSCR11′s carboxy terminus binds to retinoblastoma protein, suggesting involvement in cell cycle regulation crucial for maintaining normal cellular proliferation and differentiation.

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WBSCR11 Antibody (GTF5I102) References:

1. Identification of a putative transcription factor gene (WBSCR11) that is commonly deleted in Williams-Beuren syndrome.  |  Osborne, LR., et al. 1999. Genomics. 57: 279-84. PMID: 10198167
2. Bridging cognition, the brain and molecular genetics: evidence from Williams syndrome.  |  Bellugi, U., et al. 1999. Trends Neurosci. 22: 197-207. PMID: 10322491
3. Williams-Beuren syndrome: an update and review for the primary physician.  |  Lashkari, A., et al. 1999. Clin Pediatr (Phila). 38: 189-208. PMID: 10326175
4. A transcription factor involved in skeletal muscle gene expression is deleted in patients with Williams syndrome.  |  Tassabehji, M., et al. 1999. Eur J Hum Genet. 7: 737-47. PMID: 10573005
5. Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I.  |  Yan, X., et al. 2000. Biochem J. 345 Pt 3: 749-57. PMID: 10642537
6. Isolation and characterization of BEN, a member of the TFII-I family of DNA-binding proteins containing distinct helix-loop-helix domains.  |  Bayarsaihan, D. and Ruddle, FH. 2000. Proc Natl Acad Sci U S A. 97: 7342-7. PMID: 10861001
7. Natural history of Williams syndrome: physical characteristics.  |  Morris, CA., et al. 1988. J Pediatr. 113: 318-26. PMID: 2456379

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-WBSCR11 Antibody (GTF5I102) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-WBSCR11 Antibody (GTF5I102) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

WBSCR11 Antibody (GTF5I102) Specifications

Alternate Product Name: WBSCR11

Product Clone Name: GTF5I102

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: WBSCR11

Epitope Species: human

Product Reactivity/Detection: WBSCR11

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for WBSCR11 Antibody (GTF5I102): N/A