WAVE3 Antibody (E-3): sc-515303

WAVE3 Antibody (E-3) is a mouse monoclonal IgM antibody that detects WAVE3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WAVE3 Antibody (E-3) is available as the non-conjugated anti-WAVE3 antibody (E-3). WAVE3 plays a crucial role in actin cytoskeletal dynamics, which is essential for various cellular processes, including cell motility, shape changes, and signal transduction. WAVE3 (E-3) antibody recognizes a protein involved in the formation of a multiprotein complex that connects receptor kinases to the actin cytoskeleton, facilitating the transduction of signals that lead to alterations in cell function and movement. This interaction is vital for processes such as cell migration and morphogenesis, making WAVE3 a significant player in both normal physiological functions and pathological conditions, including cancer metastasis. The WAVE family, including WAVE1 and WAVE2, cooperates with the Arp2/3 complex to promote actin filament formation, thereby influencing cellular architecture and behavior. WAVE3 mediates actin polymerization in response to GTP binding and activation of Rac, underscoring its importance in maintaining cellular integrity and facilitating dynamic responses to environmental cues.

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WAVE3 Antibody (E-3) References:

1. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex.  |  Machesky, LM., et al. 1999. Proc Natl Acad Sci U S A. 96: 3739-44. PMID: 10097107
2. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.  |  Rohatgi, R., et al. 1999. Cell. 97: 221-31. PMID: 10219243
3. Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly.  |  Prehoda, KE., et al. 1999. Cell. 97: 471-80. PMID: 10338211
4. Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.  |  Suetsugu, S., et al. 1999. Biochem Biophys Res Commun. 260: 296-302. PMID: 10381382
5. WAVE3-NFκB interplay is essential for the survival and invasion of cancer cells.  |  Davuluri, G., et al. 2014. PLoS One. 9: e110627. PMID: 25329315
6. WAVE3 Induces EMT and Promotes Migration and Invasion in Intrahepatic Cholangiocarcinoma.  |  Zhu, Z., et al. 2016. Dig Dis Sci. 61: 1950-60. PMID: 26971088
7. The WAVE3/β-catenin oncogenic signaling regulates chemoresistance in triple negative breast cancer.  |  Wang, W., et al. 2023. Breast Cancer Res. 25: 31. PMID: 36949468
8. Role of WAVE3 as an actin binding protein in the pathology of triple negative breast cancer.  |  Master, K., et al. 2025. Cytoskeleton (Hoboken). 82: 130-144. PMID: 39021344
9. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.  |  Symons, M., et al. 1996. Cell. 84: 723-34. PMID: 8625410
10. SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development.  |  Bear, JE., et al. 1998. J Cell Biol. 142: 1325-35. PMID: 9732292
11. WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac.  |  Miki, H., et al. 1998. EMBO J. 17: 6932-41. PMID: 9843499
12. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.  |  Machesky, LM. and Insall, RH. Curr Biol. 8: 1347-56. PMID: 9889097

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-WAVE3 Antibody (E-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-WAVE3 Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

WAVE3 Antibody (E-3) Specifications

Alternate Product Name: WAVE3

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 250-269

Epitope Target: WAVE3

Epitope Species: human

Product Reactivity/Detection: WAVE3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for WAVE3 Antibody (E-3): P: Blocking Peptide

The preferred WAVE antibody is WAVE Antibody (F-10): sc-365165.