WAVE2 Antibody (B-9): sc-515651

WAVE2 Antibody (B-9) is a mouse monoclonal IgG2a antibody that detects WAVE2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WAVE2, a member of the WAVE protein family, plays a crucial role in actin cytoskeleton dynamics, particularly in the regulation of membrane ruffling and the formation of actin filament clusters in response to GTP binding. WAVE2 is essential for cellular processes such as migration, shape change, and signal transduction, as WAVE2 interacts with the Arp2/3 complex to promote actin polymerization. WAVE2 is predominantly expressed in peripheral blood leukocytes, highlighting WAVE2′s importance in immune responses and cell motility. WAVE2′s ability to form multiprotein complexes that link receptor kinases with actin underscores WAVE2′s role in translating extracellular signals into cellular responses, making WAVE2 a vital component in understanding cellular behavior in various physiological and pathological contexts. anti-WAVE2 antibody (B-9) is an invaluable tool for researchers investigating the intricate mechanisms of actin dynamics and cellular signaling pathways.

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WAVE2 Antibody (B-9) References:

1. WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.  |  Yan, C., et al. 2003. EMBO J. 22: 3602-12. PMID: 12853475
2. WAVE2 is required for directed cell migration and cardiovascular development.  |  Yamazaki, D., et al. 2003. Nature. 424: 452-6. PMID: 12879075
3. Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac.  |  Suetsugu, S., et al. 2006. J Cell Biol. 173: 571-85. PMID: 16702231
4. WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl.  |  Bryce, NS., et al. 2013. PLoS One. 8: e64533. PMID: 23691243
5. Down-regulation of WAVE2, WASP family verprolin-homologous protein 2, in gastric cancer indicates lymph node metastasis and cell migration.  |  Jia, S., et al. 2014. Anticancer Res. 34: 2185-94. PMID: 24778020
6. A conformational change within the WAVE2 complex regulates its degradation following cellular activation.  |  Joseph, N., et al. 2017. Sci Rep. 7: 44863. PMID: 28332566
7. WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4.  |  Taniuchi, K., et al. 2018. Cancer Med. 7: 5733-5751. PMID: 30353690
8. WAVE2 Enhanced Hepatic Stellate Cells Activity in Colorectal Liver Metastases.  |  Tan, F., et al. 2020. Cancer Manag Res. 12: 7671-7680. PMID: 32904432
9. WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity.  |  Liu, M., et al. 2021. Science. 371: PMID: 33766857
10. The WAVE2/miR-29/Integrin-β1 Oncogenic Signaling Axis Promotes Tumor Growth and Metastasis in Triple-negative Breast Cancer.  |  Rana, PS., et al. 2023. Cancer Res Commun. 3: 160-174. PMID: 36968231

The preferred WAVE2 antibody is WAVE2 Antibody (C-6): sc-373889.