WAVE1 Antibody (30): sc-136120
- WAVE1 Antibody (30) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 191-290 of WAVE1 of human origin
- recommended for detection of WAVE1 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for WAVE1 Antibody (30). This work is in progress.
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WAVE1 Antibody (30) is a mouse monoclonal IgG1 antibody that detects WAVE1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). WAVE1, also known as SCAR (suppressor of cAR), plays a crucial role in actin dynamics, particularly in the regulation of membrane ruffling and the formation of actin filament clusters in response to GTP binding and Rac activation. WAVE1 is primarily expressed in the brain, where WAVE1 is essential for neuronal development and function, as WAVE1 facilitates the organization of the cytoskeleton, which is vital for processes such as cell migration, synaptic plasticity, and overall cellular architecture. The interaction of WAVE1 with the Arp2/3 complex is particularly important, as WAVE1 serves as a nucleation core that promotes the formation of new actin filaments, thereby driving cellular responses to external signals. Anti-WAVE1 antibody (30) enables researchers to gain insights into the mechanisms of actin polymerization and its implications in various physiological and pathological processes, including neurodevelopmental disorders and cancer metastasis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
WAVE1 Antibody (30) References:
- Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. | Kim, Y., et al. 2006. Nature. 442: 814-7. PMID: 16862120
- WAVE1 and regulation of actin nucleation in myelination. | Sloane, JA. and Vartanian, TK. 2007. Neuroscientist. 13: 486-91. PMID: 17901257
- A novel role for WAVE1 in controlling actin network growth rate and architecture. | Sweeney, MO., et al. 2015. Mol Biol Cell. 26: 495-505. PMID: 25473116
- Cyclosporine A protects podocytes by regulating WAVE1 phosphorylation. | Li, X., et al. 2015. Sci Rep. 5: 17694. PMID: 26634693
- The Association Between WAVE1 and -3 and the ARP2/3 Complex in PC 3 Cells. | Weeks, HP., et al. 2016. Anticancer Res. 36: 1135-42. PMID: 26977009
- Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice. | Chen, Y., et al. 2018. PLoS One. 13: e0199341. PMID: 30352064
- WAVE1 and WAVE2 have distinct and overlapping roles in controlling actin assembly at the leading edge. | Tang, Q., et al. 2020. Mol Biol Cell. 31: 2168-2178. PMID: 32697617
- Estimating the wave 1 and wave 2 infection fatality rates from SARS-CoV-2 in India. | Purkayastha, S., et al. 2021. BMC Res Notes. 14: 262. PMID: 34238344
- Validation of the Wave 1 and Wave 2 Population Assessment of Tobacco and Health (PATH) Study Indicators of Tobacco Dependence Using Biomarkers of Nicotine Exposure Across Tobacco Products. | Strong, DR., et al. 2022. Nicotine Tob Res. 24: 10-19. PMID: 34383052
- Comparison of characteristics and outcomes of patients admitted to hospital with COVID-19 during wave 1 and wave 2 of the current pandemic. | Fluck, D., et al. 2022. Intern Emerg Med. 17: 675-684. PMID: 34637079
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WAVE1 Antibody (30) | sc-136120 | 50 µg/0.5 ml | $322.00 |