VPS18 Antibody (237.1): sc-100890

VPS18 Antibody (237.1) is a mouse monoclonal IgG3 kappa light chain antibody that detects VPS18 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-VPS18 antibody (237.1) is available as a non-conjugated format. VPS18, also known as vacuolar protein sorting 18 or PEP3, is a crucial 973 amino acid peripheral membrane protein that plays a significant role in protein trafficking to the vacuole, essential for maintaining cellular homeostasis and function. VPS18 (237.1) antibody targets a protein predominantly localized to late endosomes, where VPS18 is involved in membrane docking reactions and vesicle-mediated protein trafficking to lysosomal compartments. VPS18 facilitates proper sorting and delivery of proteins, vital for cellular processes such as nutrient uptake and waste disposal. VPS18 is expressed ubiquitously, with highest levels found in heart and lowest in lung, and exists in a large hetero-oligomeric complex with other vacuolar sorting proteins, including VPS11 and VPS16. VPS18 contains one clathrin repeat and one RING-type zinc finger, and two isoforms arise from alternative splicing events, highlighting the complexity and regulatory mechanisms governing VPS18 function.

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VPS18 Antibody (237.1) References:

1. Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33.  |  Huizing, M., et al. 2001. Gene. 264: 241-7. PMID: 11250079
2. Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7.  |  Kim, BY., et al. 2001. J Biol Chem. 276: 29393-402. PMID: 11382755
3. Aspergillus nidulans DigA, a potential homolog of Saccharomyces cerevisiae Pep3 (Vps18), is required for nuclear migration, mitochondrial morphology and polarized growth.  |  Geissenhöner, A., et al. 2001. Mol Genet Genomics. 266: 672-85. PMID: 11810240
4. Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex.  |  Kim, BY., et al. 2003. Biochem Biophys Res Commun. 311: 577-82. PMID: 14623309
5. Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase.  |  Yogosawa, S., et al. 2005. J Biol Chem. 280: 41619-27. PMID: 16203730
6. The zebrafish mutant vps18 as a model for vesicle-traffic related hypopigmentation diseases.  |  Maldonado, E., et al. 2006. Pigment Cell Res. 19: 315-26. PMID: 16827750
7. Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability.  |  Yogosawa, S., et al. 2006. Biochem Biophys Res Commun. 350: 82-90. PMID: 16996030

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VPS18 Antibody (237.1) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-VPS18 Antibody (237.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VPS18 Antibody (237.1) Specifications

Alternate Product Name: VPS18

Product Clone Name: 237.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 3-101

Epitope Target: VPS18

Epitope Species: human

Product Reactivity/Detection: VPS18

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG₃ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for VPS18 Antibody (237.1): N/A