Vitronectin 65/75 Antibody (B-1): sc-74485

Vitronectin 65/75 Antibody (B-1) is a mouse monoclonal IgG1 antibody that detects Vitronectin in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Vitronectin is a crucial extracellular matrix glycoprotein that plays a significant role in cell adhesion, motility, and wound healing, making it vital for tissue repair and regeneration. Vitronectin is primarily located in the extracellular matrix and plasma, where Vitronectin interacts with integrins and other adhesion molecules to facilitate cell attachment and migration. The presence of the RGD (Arg-Gly-Asp) sequence within Vitronectin is particularly important, as this sequence is essential for binding to integrins, thereby promoting cell adhesion. Furthermore, the dynamic regulation of Vitronectin levels during wound healing is critical; increased expression has been observed in migrating cells, which enhances their ability to move and repair damaged tissues. Additionally, the interaction of Vitronectin with plasminogen activators and Vitronectin cleavage by plasmin can modulate binding affinity for other proteins, such as PAI-1, influencing cell migration and tissue remodeling. Anti-Vitronectin antibody (B-1) is an invaluable tool for researchers studying these processes and the underlying mechanisms of cell behavior in various physiological and pathological contexts.

The preferred Vitronectin 65/75 antibody is Vitronectin 65/75 Antibody (D-8): sc-74484.