Visual Arrestin Antibody (B-2): sc-166068

Visual Arrestin Antibody (B-2) is a mouse monoclonal IgG3 kappa light chain antibody designed to detect Visual Arrestin, also known as Arrestin 1, retinal S-antigen, or S-Arrestin, across multiple species including human, mouse, and rat. anti-Visual Arrestin antibody (B-2) is raised against amino acids 316-405 at the C-terminus of the human Visual Arrestin protein, ensuring effective binding for reliable detection in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Visual Arrestin plays a critical role in the phototransduction pathway by binding to phosphorylated rhodopsin, thereby terminating the light signal and preventing continuous activation of G protein-coupled receptors. This function is essential for maintaining accurate visual perception and preventing signal desensitization, allowing organisms to respond appropriately to changes in light conditions. Additionally, Visual Arrestin is expressed in the pineal gland, where Visual Arrestin contributes to the regulation of circadian rhythms, highlighting Visual Arrestin′s importance in both vision and overall physiological regulation. The ability of Visual Arrestin to modulate receptor activity makes Visual Arrestin a key player in cellular responses to light and other stimuli, influencing processes such as neurotransmission and cellular adaptation. Visual Arrestin (B-2) antibody facilitates detailed studies of Visual Arrestin′s function and regulation, aiding research into visual signal transduction, retinal diseases, and autoimmune conditions like uveoretinitis and Oguchi disease.

The preferred β-Arrestin-2 antibody is β-Arrestin-2 Antibody (H-9): sc-13140.