VIPL Antibody (A-4): sc-514840

VIPL Antibody (A-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects VIPL protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). VIPL (A-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. VIPL protein, also known as LMAN2L (lectin, mannose-binding 2-like), is a 348 amino acid single-pass type I membrane protein that plays a crucial role in the selective transport of newly synthesized glycoproteins from the endoplasmic reticulum to the ER-Golgi intermediate compartment. VIPL protein is primarily localized in the endoplasmic reticulum and Golgi apparatus, where VIPL protein is essential for the proper export of glycoproteins, thereby influencing various cellular processes, including protein folding and quality control. VIPL protein is highly expressed in skeletal muscle and kidney, with intermediate levels in heart, liver, and placenta, while exhibiting low expression in brain, thymus, spleen, small intestine, and lung. VIPL protein contains one L-type lectin-like domain and functions as a regulator of ERGIC-53, indicating importance in maintaining cellular homeostasis and protein trafficking. Additionally, VIPL protein exists in two alternatively spliced isoforms, which may contribute to functional diversity in different tissues.

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VIPL Antibody (A-4) References:

1. Profile-based data base scanning for animal L-type lectins and characterization of VIPL, a novel VIP36-like endoplasmic reticulum protein.  |  Nufer, O., et al. 2003. J Biol Chem. 278: 15886-96. PMID: 12609988
2. Lectins and protein traffic early in the secretory pathway.  |  Hauri, HP., et al. 2002. Biochem Soc Symp. 73-82. PMID: 12655775
3. VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum.  |  Neve, EP., et al. 2003. Exp Cell Res. 288: 70-83. PMID: 12878160
4. The binding of VIP36 and alpha-amylase in the secretory vesicles via high-mannose type glycans.  |  Hara-Kuge, S., et al. 2004. Glycobiology. 14: 739-44. PMID: 15070860
5. Sugar-binding properties of VIP36, an intracellular animal lectin operating as a cargo receptor.  |  Kamiya, Y., et al. 2005. J Biol Chem. 280: 37178-82. PMID: 16129679
6. Oligomerization and interacellular localization of the glycoprotein receptor ERGIC-53 is independent of disulfide bonds.  |  Neve, EP., et al. 2005. J Mol Biol. 354: 556-68. PMID: 16257008
7. Molecular basis of sugar recognition by the human L-type lectins ERGIC-53, VIPL, and VIP36.  |  Kamiya, Y., et al. 2008. J Biol Chem. 283: 1857-61. PMID: 18025080
8. A dual role for COOH-terminal lysine residues in pre-Golgi retention and endocytosis of ERGIC-53.  |  Kappeler, F., et al. 1994. J Biol Chem. 269: 6279-81. PMID: 8119975
9. ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif.  |  Schindler, R., et al. 1993. Eur J Cell Biol. 61: 1-9. PMID: 8223692

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VIPL Antibody (A-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-VIPL Antibody (A-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VIPL Antibody (A-4) Specifications

Alternate Product Name: VIPL

Product Clone Name: A-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 282-348

Epitope Target: VIPL

Epitope Species: human

Product Reactivity/Detection: VIPL

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for VIPL Antibody (A-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin