Villin Antibody (12): sc-136119

Villin Antibody (12) is a mouse monoclonal IgG1 antibody that detects Villin in human and bovine samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications. Anti-Villin antibody (12) specifically targets Villin, a crucial actin-binding protein that plays a significant role in the structure and function of brush border microvilli in absorptive epithelial cells. Villin (12) monoclonal antibody recognizes a protein essential for maintaining the integrity and organization of microvilli, which are vital for nutrient absorption in the intestines. Villin is regulated by calcium ions, and Villin′s ability to polymerize actin filaments is critical for dynamic remodeling of the cytoskeleton in response to cellular signals. Villin (12) antibody identifies a protein that contributes to mechanical stability of the brush border and influences cell signaling pathways important for cellular processes such as migration and proliferation. With unique properties and functions, Villin serves as a key player in maintaining cellular architecture and facilitating efficient nutrient uptake, making anti-Villin antibody (12) an invaluable tool for researchers studying epithelial cell biology and related disorders.

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Villin Antibody (12) References:

1. Tyrosine phosphorylation of villin regulates the organization of the actin cytoskeleton.  |  Zhai, L., et al. 2001. J Biol Chem. 276: 36163-7. PMID: 11500485
2. Loss of villin immunoexpression in colorectal carcinoma is associated with poor differentiation and survival.  |  Al-Maghrabi, J., et al. 2013. ISRN Gastroenterol. 2013: 679724. PMID: 24083028
3. Autoantibodies to harmonin and villin are diagnostic markers in children with IPEX syndrome.  |  Lampasona, V., et al. 2013. PLoS One. 8: e78664. PMID: 24250806
4. Prevention of Cell Growth by Suppression of Villin Expression in Lithocholic Acid-Stimulated HepG2 Cells.  |  Ozeki, M., et al. 2019. J Histochem Cytochem. 67: 129-141. PMID: 30303767
5. Villin, a specific marker for some epithelia specialized in transport, to study the differentiation of intestinal and kidney cells in vivo and in a human colon adenocarcinoma line HT29 in culture.  |  Arpin, M., et al. 1988. Mol Aspects Med. 10: 257-72. PMID: 3068455
6. Prognostic Value of CDX2 and Villin Expression in Advanced Stage Colorectal Carcinoma.  |  Altintas, S., et al. 2019. J Coll Physicians Surg Pak. 29: 1057-1061. PMID: 31659962
7. Topological data analysis gives two folding paths in HP35(nle-nle), double mutant of villin headpiece subdomain.  |  Ichinomiya, T. 2022. Sci Rep. 12: 2719. PMID: 35177744
8. Revealing the biotoxicity of phosphorene oxide nanosheets based on the villin headpiece.  |  Zhang, W., et al. 2023. Phys Chem Chem Phys. 25: 3100-3109. PMID: 36621815
9. Slow methyl axes motions in perdeuterated villin headpiece subdomain probed by cross-correlated NMR relaxation measurements.  |  Vugmeyster, L., et al. 2023. Magnetochemistry. 9: PMID: 36776538
10. The utility of the lineage specific immunohistochemical stains SATB2, CDX2, and villin, and the mucin glycoproteins MUC2, MUC5AC, and MUC6 to distinguish pulmonary invasive mucinous adenocarcinoma from metastatic colorectal carcinoma.  |  Rerkpichaisuth, V., et al. 2024. Hum Pathol. 151: 105627. PMID: 39029534

The preferred Villin antibody is Villin Antibody (1D2C3): sc-58897.