versican Antibody (5C1): sc-47777

Versican Antibody (5C1) is a mouse monoclonal IgG antibody that detects versican in human and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Versican is a large extracellular matrix proteoglycan that plays a crucial role in cell growth and differentiation, serving as a vital structural component that forms loose and hydrated matrices during significant developmental and pathological processes. Anti-versican antibody (5C1) recognizes a protein structure that includes hyaluronic acid and glycosaminoglycan-binding domains, epidermal growth factor-like repeats, a lectin-like sequence, and a complement regulatory protein-like domain, which collectively contribute to diverse biological functions. Notably, versican′s splice variants exhibit considerable variability in length and glycosaminoglycan modification, influencing interactions and roles in various tissues. Versican accumulation around smooth muscle cells in atherosclerotic lesions indicates potential involvement in atherogenesis, while differential expression in human melanoma suggests a significant role in tumor development, making versican a promising marker for clinical diagnosis. Furthermore, the organization of hyaluronic acid and versican-rich pericellular matrices facilitates cell migration and mitosis by reducing cell surface adhesivity and altering cell shape through steric exclusion and the viscous properties of hyaluronic acid proteoglycan gels. The human versican gene is located on chromosome 5q14.3, underscoring importance in both normal physiology and disease states. Versican monoclonal antibody (5C1) serves as an essential tool for researchers investigating the multifaceted roles of versican in health and disease.

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versican Antibody (5C1) References:

1. The interaction of versican with its binding partners.  |  Wu, YJ., et al. 2005. Cell Res. 15: 483-94. PMID: 16045811
2. Structure, function and regulation of versican: the most abundant type of proteoglycan in the extracellular matrix.  |  Sotoodehnejadnematalahi, F. and Burke, B. 2013. Acta Med Iran. 51: 740-50. PMID: 24390942
3. A role for versican in the development of leiomyosarcoma.  |  Keire, PA., et al. 2014. J Biol Chem. 289: 34089-103. PMID: 25320080
4. Versican in inflammation and tissue remodeling: the impact on lung disorders.  |  Andersson-Sjöland, A., et al. 2015. Glycobiology. 25: 243-51. PMID: 25371494
5. Isolation and Purification of Versican and Analysis of Versican Proteolysis.  |  Foulcer, SJ., et al. 2022. Methods Mol Biol. 2303: 559-578. PMID: 34626407
6. Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination.  |  Ghorbani, S., et al. 2022. Nat Commun. 13: 2445. PMID: 35508608
7. Versican enrichment predicts poor prognosis and response to adjuvant therapy and immunotherapy in gastric cancer.  |  Song, J., et al. 2022. Front Immunol. 13: 960570. PMID: 36203562
8. Versican provides the provisional matrix for uterine spiral artery dilation and fetal growth.  |  Sagae, Y., et al. 2023. Matrix Biol. 115: 16-31. PMID: 36423736
9. Non-Oncogene Addiction of KRAS-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ.  |  Spella, M., et al. 2023. Cancers (Basel). 15: PMID: 36980752
10. Versican maintains the homeostasis of adipose tissues and regulates energy metabolism.  |  Arbee, S., et al. 2024. Biochem Biophys Res Commun. 727: 150309. PMID: 38936224

The preferred versican antibody is versican Antibody (4C5): sc-47769.