VCC-1 Antibody (B-3): sc-398842

VCC-1 Antibody (B-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects VCC-1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). VCC-1 (B-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. VCC-1, also known as VEGF co-regulated chemokine 1, Dcip1, DMC (dendritic cell and monocyte chemokine-like protein), or CXCL17 (C-X-C motif chemokine 17), is a 119 amino acid secreted protein that plays a crucial role in angiogenesis and immune response. VCC-1 is primarily located in tissues such as skeletal muscle, trachea, lung, intestine, and stomach, where VCC-1 is involved in recruiting immature dendritic cells and non-activated blood monocytes into tissues, thereby facilitating innate immune response. VCC-1 is upregulated in duodenal mucosa of patients suffering from acute cholera and in breast tumors, highlighting VCC-1′s potential significance in pathological conditions. VCC-1′s encoding gene is mapped to human chromosome 19q13.2 and mouse chromosome 7 A3, making VCC-1 an important target for research in both human and murine models.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

VCC-1 Antibody (B-3) References:

1. Signal peptide prediction based on analysis of experimentally verified cleavage sites.  |  Zhang, Z. and Henzel, WJ. 2004. Protein Sci. 13: 2819-24. PMID: 15340161
2. Cutting edge: novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods.  |  Pisabarro, MT., et al. 2006. J Immunol. 176: 2069-73. PMID: 16455961
3. VCC-1, a novel chemokine, promotes tumor growth.  |  Weinstein, EJ., et al. 2006. Biochem Biophys Res Commun. 350: 74-81. PMID: 16989774
4. The chemokine and chemokine receptor superfamilies and their molecular evolution.  |  Zlotnik, A., et al. 2006. Genome Biol. 7: 243. PMID: 17201934
5. Broad up-regulation of innate defense factors during acute cholera.  |  Flach, CF., et al. 2007. Infect Immun. 75: 2343-50. PMID: 17307946
6. Overexpression of VCC-1 gene in human hepatocellular carcinoma cells promotes cell proliferation and invasion.  |  Mu, X., et al. 2009. Acta Biochim Biophys Sin (Shanghai). 41: 631-7. PMID: 19657564
7. CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis.  |  Hiraoka, N., et al. 2011. Gastroenterology. 140: 310-21. PMID: 20955708
8. Inflammatory gene expression in OVE26 diabetic kidney during the development of nephropathy.  |  Yang, L., et al. 2011. Nephron Exp Nephrol. 119: e8-20. PMID: 21606656
9. VCC-1 over-expression inhibits cisplatin-induced apoptosis in HepG2 cells.  |  Zhou, Z., et al. 2012. Biochem Biophys Res Commun. 420: 336-42. PMID: 22425983
10. CXCL17 expression by tumor cells recruits CD11b+Gr1 high F4/80- cells and promotes tumor progression.  |  Matsui, A., et al. 2012. PLoS One. 7: e44080. PMID: 22952881
11. Carbapenemase VCC-1-Producing Vibrio cholerae in Coastal Waters of Germany.  |  Hammerl, JA., et al. 2017. Emerg Infect Dis. 23: 1735-1737. PMID: 28930017
12. Emerging mechanisms of antimicrobial resistance in bacteria and fungi: advances in the era of genomics.  |  Sekyere, JO. and Asante, J. 2018. Future Microbiol. 13: 241-262. PMID: 29319341

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VCC-1 Antibody (B-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-VCC-1 Antibody (B-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VCC-1 Antibody (B-3) Specifications

Alternate Product Name: VCC-1

Product Clone Name: B-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 24-66

Epitope Target: VCC-1

Epitope Species: human

Product Reactivity/Detection: VCC-1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for VCC-1 Antibody (B-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin