VCAM-1 Antibody (P3C4): sc-20070

VCAM-1 Antibody (P3C4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Vascular Cell Adhesion Molecule 1 (VCAM-1) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). VCAM-1 is a transmembrane sialoglycoprotein predominantly expressed on activated endothelial cells, playing a pivotal role in mediating the adhesion of leukocytes to the endothelium during immune responses. This adhesion is crucial for the recruitment of immune cells to sites of inflammation, which is particularly significant in the context of inflammatory diseases such as atherosclerosis and rheumatoid arthritis. The structure of VCAM-1 comprises seven immunoglobulin-like domains, which are essential for high binding affinity to integrins like α4β1 and α4β7 found on leukocytes. These structural features not only facilitate leukocyte adhesion but also participate in signal transduction pathways that regulate cell survival and proliferation, underscoring VCAM-1′s importance in maintaining vascular integrity and immune function. VCAM-1 (P3C4) antibody serves as an invaluable tool for researchers aiming to elucidate the mechanisms of endothelial activation and vascular inflammation, enabling exploration of VCAM-1′s interactions with integrins and other proteins involved in immune cell trafficking and endothelial dysfunction.

The preferred VCAM-1 antibody is VCAM-1 Antibody (E-10): sc-13160.