VCAM-1 Antibody (HAE-2z): sc-13506
- VCAM-1 Antibody (HAE-2z) is a mouse monoclonal IgG1 κ, cited in 8 publications, provided at 200 µg/ml
- raised against domain 1 of VCAM-1 of human origin
- recommended for detection of VCAM-1 of human origin by IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also provided azide-free for blocking, sc-13506 L, 200 µg/0.1 ml
- See VCAM-1 (E-10): sc-13160 for VCAM-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for VCAM-1 Antibody (HAE-2z) for IHC(P) applications. These reagents are now offered in bundles with VCAM-1 Antibody (HAE-2z) (see ordering information below).
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VCAM-1 Antibody (HAE-2z) is a mouse monoclonal IgG1 antibody raised against domain 1 of human VCAM-1. Vascular Cell Adhesion Molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein expressed on endothelial cells activated by cytokines. VCAM-1 plays a crucial role in mediating the adhesion of leukocytes to the endothelium, a key step in the inflammatory response. VCAM-1 binds to the integrin VLA-4 (α4β1) on leukocytes, facilitating their transmigration across the endothelial barrier into tissues. This interaction is significant in immune surveillance and has been implicated in various pathological conditions such as atherosclerosis, rheumatoid arthritis, and multiple sclerosis. VCAM-1 expression is upregulated by pro-inflammatory cytokines like interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α), and lipopolysaccharide (LPS). Anti-VCAM-1 antibody (HAE-2z) reacts with human VCAM-1 and is suitable for applications including immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). By targeting domain 1 of VCAM-1, anti-VCAM-1 antibody (HAE-2z) aids in studying leukocyte-endothelial interactions and the mechanisms underlying inflammatory processes. Understanding VCAM-1 function is important for developing therapeutic strategies against inflammatory diseases and conditions involving abnormal immune cell trafficking.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VCAM-1 Antibody (HAE-2z) | sc-13506 | 200 µg/ml | $322.00 | |||
VCAM-1 Antibody (HAE-2z): m-IgG Fc BP-HRP Bundle | sc-538895 | 200 µg Ab; 10 µg BP | $361.00 | |||
VCAM-1 Antibody (HAE-2z): m-IgG1 BP-HRP Bundle | sc-541129 | 200 µg Ab; 20 µg BP | $361.00 | |||
VCAM-1 Antibody (HAE-2z) FITC | sc-13506 FITC | 200 µg/ml | $336.00 | |||
VCAM-1 Antibody (HAE-2z) L | sc-13506 L | 200 µg/0.1 ml | $322.00 | |||
VCAM-1 Antibody (HAE-2z) PE | sc-13506 PE | 200 µg/ml | $349.00 |