VAX2 Antibody (VAX2A8F12): sc-81422

VAX2 Antibody (VAX2A8F12) is a mouse monoclonal IgG1 antibody that detects VAX2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-VAX2 antibody (VAX2A8F12) is available as a non-conjugated format. VAX2, or Ventral anterior homeobox 2, is a 290 amino acid homeobox protein that plays a pivotal role in eye development, particularly in ventral optic vesicle specification and dorsoventral pattern establishment. VAX2 is localized in the nucleus, where VAX2 functions as a transcription factor, working with VAX1 to regulate retinal differentiation, neuroepithelial cell proliferation, and axial polarization in the retina. VAX2 and VAX1 repress Pax-6 transcription, a key inducer of retinal development; by inhibiting Pax-6, VAX2 effectively slows retinal differentiation, allowing proper optic nerve development. VAX2′s structural integrity is maintained by its homeobox DNA-binding domain, which is essential for gene regulation function. Understanding VAX2′s role in retinal development is crucial, as functional disruptions can lead to eye developmental disorders.

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VAX2 Antibody (VAX2A8F12) References:

1. A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis.  |  Barbieri, AM., et al. 1999. Proc Natl Acad Sci U S A. 96: 10729-34. PMID: 10485894
2. The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye.  |  Mui, SH., et al. 2002. Development. 129: 797-804. PMID: 11830578
3. Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma.  |  Barbieri, AM., et al. 2002. Development. 129: 805-13. PMID: 11830579
4. Natural antisense transcripts associated with genes involved in eye development.  |  Alfano, G., et al. 2005. Hum Mol Genet. 14: 913-23. PMID: 15703187
5. Vax genes ventralize the embryonic eye.  |  Mui, SH., et al. 2005. Genes Dev. 19: 1249-59. PMID: 15905411
6. Hedgehog-regulated localization of Vax2 controls eye development.  |  Kim, JW. and Lemke, G. 2006. Genes Dev. 20: 2833-47. PMID: 17043310
7. Rybp, a polycomb complex-associated protein, is required for mouse eye development.  |  Pirity, MK., et al. 2007. BMC Dev Biol. 7: 39. PMID: 17470285
8. Retinoic acid is required for specification of the ventral eye field and for Rathke's pouch in the avian embryo.  |  Maden, M., et al. 2007. Int J Dev Biol. 51: 191-200. PMID: 17486539
9. First insights into the expression of VAX2 in humans and its localization in the adult primate retina.  |  Alfano, G., et al. 2016. Exp Eye Res. 148: 24-29. PMID: 27179412
10. cnd-1/NeuroD1 Functions with the Homeobox Gene ceh-5/Vax2 and Hox Gene ceh-13/labial To Specify Aspects of RME and DD Neuron Fate in Caenorhabditis elegans.  |  Aquino-Nunez, W., et al. 2020. G3 (Bethesda). 10: 3071-3085. PMID: 32601060
11. Depletion of VAX2 Restrains the Malignant Progression of Papillary Thyroid Carcinoma by Modulating ERK Signaling Pathway.  |  Guo, B., et al. 2019. Open Life Sci. 14: 237-245. PMID: 33817157
12. The VAX2-LINC01189-hnRNPF signaling axis regulates cell invasion and migration in gastric cancer.  |  Hong, L., et al. 2023. Cell Death Discov. 9: 387. PMID: 37865686

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VAX2 Antibody (VAX2A8F12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-VAX2 Antibody (VAX2A8F12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VAX2 Antibody (VAX2A8F12) Specifications

Alternate Product Name: VAX2

Product Clone Name: VAX2A8F12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: VAX2

Epitope Species: human

Product Reactivity/Detection: VAX2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for VAX2 Antibody (VAX2A8F12): N/A