Vaccinia Virus Antibody (8118): sc-69950

Vaccinia Virus Antibody (8118) is a mouse monoclonal IgG1 antibody that detects Vaccinia Virus by immunofluorescence (IF). Vaccinia Virus is a member of the poxvirus family and contains double-stranded DNA, historically significant for its role in the eradication of smallpox through vaccination. The fusion protein, encoded by the Vaccinia Virus A27L gene, is crucial for the entry of intracellular enveloped virus (IEV) into host cells, facilitating both virus-to-cell and cell-to-cell fusions. This protein is essential for the microtubule-dependent transport of intracellular mature virus particles and is involved in the envelopment process that leads to IEV formation. Notably, the N-terminus of the fusion protein recognizes heparan sulfate on the cell surface, allowing interaction with the negatively charged sulfates of glycosaminoglycans (GAGs), which is vital for virus infection of host cells. Anti-Vaccinia Virus antibody (8118) not only aids in neutralizing Vaccinia Virus infections but also serves as a valuable tool for identifying other viral and cellular proteins involved in the entry process of the virus, thereby enhancing our understanding of viral pathogenesis and potential therapeutic interventions.

The preferred Vaccinia Virus antibody is Vaccinia Virus Antibody (8115): sc-58210.