Vaccinia Virus Antibody (8115): sc-58210

Vaccinia Virus Antibody (8115) is a mouse monoclonal IgG1 antibody that detects the Vaccinia Virus protein of Vaccinia virus origin by immunofluorescence (IF) and enzyme-linked immunosorbent assay (ELISA). Anti-Vaccinia Virus antibody (8115) is available as the non-conjugated format. Vaccinia Virus (8115) antibody plays a crucial role in studying the Vaccinia Virus, which belongs to the poxvirus family and contains double-stranded DNA. Historically, Vaccinia Virus was instrumental in the eradication of smallpox, making it a significant subject of research. The protein encoded by the Vaccinia Virus A27L gene is particularly important as it facilitates viral entry into host cells through fusion. This fusion protein is essential for the microtubule-dependent transport of intracellular mature virus particles and is involved in the envelopment process that leads to the formation of intracellular enveloped virus particles. The N-terminus of this protein has a specific affinity for heparan sulfate on the cell surface, allowing interaction with the negatively charged sulfates of glycosaminoglycans. Vaccinia Virus (8115) monoclonal antibody not only aids in neutralizing Vaccinia Virus infections but also helps identify other viral and cellular proteins integral to viral entry, thereby enhancing understanding of viral pathogenesis and potential therapeutic targets.

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Vaccinia Virus Antibody (8115) References:

1. Identification of functional domains in the 14-kilodalton envelope protein (A27L) of vaccinia virus.  |  Vázquez, MI. and Esteban, M. 1999. J Virol. 73: 9098-109. PMID: 10516016
2. The vaccinia virus A27L protein is needed for the microtubule-dependent transport of intracellular mature virus particles.  |  Sanderson, CM., et al. 2000. J Gen Virol. 81: 47-58. PMID: 10640541
3. T-bet is required for protection against vaccinia virus infection.  |  Matsui, M., et al. 2005. J Virol. 79: 12798-806. PMID: 16188982
4. Characterization of the vaccinia virus A35R protein and its role in virulence.  |  Roper, RL. 2006. J Virol. 80: 306-13. PMID: 16352555
5. Modified vaccinia virus Ankara multiplies in rat IEC-6 cells and limited production of mature virions occurs in other mammalian cell lines.  |  Okeke, MI., et al. 2006. J Gen Virol. 87: 21-27. PMID: 16361414
6. Administration of vaccinia virus complement control protein shows significant cognitive improvement in a mild injury model.  |  Pillay, NS., et al. 2005. Ann N Y Acad Sci. 1056: 450-61. PMID: 16387708
7. Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling.  |  Valderrama, F., et al. 2006. Science. 311: 377-81. PMID: 16424340
8. Analysis of vaccinia virus temperature-sensitive I7L mutants reveals two potential functional domains.  |  Moerdyk, MJ., et al. 2006. Virol J. 3: 64. PMID: 16945137
9. Inducible expression of the vaccinia virus A17L gene provides a synchronized system to monitor sorting of viral proteins during morphogenesis.  |  Rodríguez, D., et al. 1996. J Virol. 70: 7641-53. PMID: 8892884
10. The vaccinia virus 14-kilodalton (A27L) fusion protein forms a triple coiled-coil structure and interacts with the 21-kilodalton (A17L) virus membrane protein through a C-terminal alpha-helix.  |  Vázquez, MI., et al. 1998. J Virol. 72: 10126-37. PMID: 9811753

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Vaccinia Virus Antibody (8115) has 2 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Vaccinia Virus Antibody (8115) Specifications

Alternate Product Name: Vaccinia Virus

Product Clone Name: 8115

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Vaccinia Virus

Epitope Species: Vaccinia virus

Product Reactivity/Detection: free Vaccinia virus and Vaccinia virus infected cells

Species Reactivity/Detection: Vaccinia virus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Vaccinia Virus Antibody (8115): N/A