Vaccinia Virus Antibody (8116): sc-69949

Vaccinia Virus Antibody (8116) is a mouse monoclonal IgG2b antibody that detects Vaccinia Virus by immunofluorescence (IF). Anti-Vaccinia Virus antibody (8116) plays a crucial role in understanding the mechanisms of viral entry and infection, particularly through interaction with the fusion protein encoded by the Vaccinia Virus A27L gene. This protein is essential for the entry of intracellular enveloped virus (IEV) into host cells, facilitating both virus-to-cell and cell-to-cell fusions. The N-terminus of the fusion protein specifically recognizes heparan sulfate on the cell surface, allowing interaction with the negatively charged sulfates of glycosaminoglycans (GAGs), which is vital for the virus′s ability to attach and penetrate host cells. Vaccinia Virus monoclonal antibody (8116) helps researchers effectively neutralize Vaccinia Virus infections and identify other viral and cellular proteins involved in the entry process, thereby advancing understanding of viral pathogenesis and potential therapeutic targets.

The preferred Vaccinia Virus antibody is Vaccinia Virus Antibody (8115): sc-58210.