V-ATPase C2 Antibody (S-10): sc-81888

V-ATPase C2 Antibody (S-10) is a mouse monoclonal IgG2b kappa light chain antibody that detects V-ATPase C2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-V-ATPase C2 antibody (S-10) is available as the non-conjugated form. The vacuolar-type H+-ATPase (V-ATPase) plays a crucial role in maintaining cellular homeostasis by acidifying various intracellular organelles, which is essential for processes such as protein sorting, nutrient uptake, and the activation of certain enzymes. The V-ATPase is composed of a peripheral V1 domain responsible for ATP hydrolysis and an integral V0 domain that facilitates proton translocation, with the V1 domain consisting of nine subunits (A-H) and the V0 domain made up of five subunits (a, d, c, c′, and c"). V-ATPase C2, also known as ATP6V1C2, ATP6C2, or VMA5, is a member of the V-ATPase C subunit family and is specifically expressed in lung and kidney tissues. This subunit is vital for the proper assembly of the catalytic portion of the V-ATPase enzyme and may also possess a specific catalytic function, highlighting its importance in the overall activity of the V-ATPase complex. The ability of V-ATPase to pump protons against an electrochemical gradient is critical for various physiological processes, making V-ATPase C2 a significant target for research in cellular metabolism and organelle function.

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V-ATPase C2 Antibody (S-10) References:

1. Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis.  |  Smith, AN., et al. 2002. Gene. 297: 169-77. PMID: 12384298
2. Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits.  |  Sun-Wada, GH., et al. 2003. Gene. 302: 147-53. PMID: 12527205
3. Mouse proton pump ATPase C subunit isoforms (C2-a and C2-b) specifically expressed in kidney and lung.  |  Sun-Wada, GH., et al. 2003. J Biol Chem. 278: 44843-51. PMID: 12947086
4. Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis.  |  Jouret, F., et al. 2005. J Am Soc Nephrol. 16: 3235-46. PMID: 16177003
5. Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis.  |  Pietrement, C., et al. 2006. Biol Reprod. 74: 185-94. PMID: 16192400
6. A novel autosomal recessive non-syndromic hearing impairment locus (DFNB47) maps to chromosome 2p25.1-p24.3.  |  Hassan, MJ., et al. 2006. Hum Genet. 118: 605-10. PMID: 16261342
7. Differential expression of a V-type ATPase C subunit gene, Atp6v1c2, during culture of rat lung type II pneumocytes.  |  Feng, NH., et al. 2005. J Biomed Sci. 12: 899-911. PMID: 16283434
8. Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis.  |  Xu, J., et al. 2007. Histol Histopathol. 22: 443-54. PMID: 17290355

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-V-ATPase C2 Antibody (S-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-V-ATPase C2 Antibody (S-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

V-ATPase C2 Antibody (S-10) Specifications

Alternate Product Name: V-ATPase C2

Product Clone Name: S-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 188-254

Epitope Target: V-ATPase C2

Epitope Species: human

Product Reactivity/Detection: V-ATPase C2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for V-ATPase C2 Antibody (S-10): N/A