UTX Antibody (D-3): sc-514860
- UTX Antibody (D-3) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 732-754 within an internal region of UTX of human origin
- recommended for detection of UTX of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for UTX Antibody (D-3). This work is in progress.
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UTX Antibody (D-3) is a mouse monoclonal IgG2a antibody that detects UTX in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UTX, or ubiquitously transcribed tetratricopeptide repeat, X chromosome, is a crucial 1,401 amino acid nuclear protein that plays a significant role in the regulation of gene expression by functioning as a histone demethylase. UTX is essential for modulating the histone code, specifically through the demethylation of lysine residues on Histone H3, which influences chromatin structure and accessibility, thereby impacting transcriptional regulation. UTX is particularly important in the context of Hox gene expression, which is vital for proper embryonic development and cellular differentiation. UTX contains one JMJC domain and eight TPR repeats, which are critical for interaction with other proteins, including TLE1, a key player in the Notch signaling pathway. By understanding UTX function and significance, researchers can gain insights into various developmental processes and potential dysregulations associated with diseases, making anti-UTX antibody (D-3) an invaluable tool for studying these complex biological mechanisms.
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UTX Antibody (D-3) References:
- The Roles of Histone Demethylase UTX and JMJD3 (KDM6B) in Cancers: Current Progress and Future Perspectives. | Xiao, ZG., et al. 2016. Curr Med Chem. 23: 3687-3696. PMID: 27458035
- UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes. | Sera, Y., et al. 2021. Blood. 137: 908-922. PMID: 33174606
- Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma. | Yi, J., et al. 2021. Cancer Lett. 499: 188-200. PMID: 33253789
- EGFR transcriptionally upregulates UTX via STAT3 in non-small cell lung cancer. | Zhou, L., et al. 2022. J Cancer Res Clin Oncol. 148: 309-319. PMID: 34661759
- Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration. | Lian, WS., et al. 2022. Cell Death Dis. 13: 538. PMID: 35676242
- UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death. | Koizumi, M., et al. 2022. FASEB J. 36: e22662. PMID: 36412518
- Hydroxyphenylpyruvate Dioxygenase Is a Metabolic Immune Checkpoint for UTX-deficient Colorectal Cancer. | Du, Z., et al. 2023. Gastroenterology. 164: 1165-1179.e13. PMID: 36813208
- The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences. | Cheng, MI., et al. 2023. Nat Immunol. 24: 780-791. PMID: 36928413
- UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease. | Rizq, O., et al. 2023. Leukemia. 37: 1895-1907. PMID: 37198323
- Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression. | Zhang, HQ., et al. 2024. Genes Dis. 11: 921-934. PMID: 37692474
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UTX Antibody (D-3) | sc-514860 | 200 µg/ml | $322.00 | |||
UTX (D-3) Neutralizing Peptide | sc-514860 P | 100 µg/0.5 ml | $69.00 |