UTX Activators
UTX, also known as KDM6A, is a histone demethylase that plays a pivotal role in chromatin remodeling and gene expression regulation. Its main function is to remove methyl groups from lysine 27 on histone H3 (H3K27), thereby facilitating transcriptional activation of target genes. This process leads to the transition from repressive to permissive chromatin states, allowing for the expression of genes involved in various cellular processes such as development, differentiation, and cellular identity. UTX is an essential component of the COMPASS-like complex, which includes histone methyltransferase MLL4 (KMT2D) and other associated proteins. Together, these proteins form a dynamic regulatory network that governs epigenetic modifications and gene expression patterns crucial for cellular function and homeostasis.
Activation of UTX is intricately regulated through multiple mechanisms that control its enzymatic activity and cellular localization. One of the primary modes of activation involves post-translational modifications (PTMs) such as phosphorylation, acetylation, and ubiquitination, which modulate UTX function. PTMs can either directly influence the catalytic activity of UTX or regulate its interactions with other proteins within the COMPASS-like complex, thereby impacting its overall function. Additionally, cellular signaling pathways and transcription factors can regulate UTX expression levels, leading to changes in its enzymatic activity and chromatin-modifying capabilities. Furthermore, the recruitment of UTX to specific genomic loci by transcriptional activators or chromatin remodeling complexes facilitates its activation and target gene expression. Overall, the activation of UTX is a tightly regulated process orchestrated by a complex interplay of biochemical modifications and molecular interactions that govern epigenetic regulation and gene expression dynamics.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA, or suberoylanilide hydroxamic acid, is a UTX activator that promotes histone acetylation by inhibiting histone deacetylases (HDACs). By inhibiting HDACs, SAHA increases the acetylation of histones, including H3K27, leading to enhanced UTX activity. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
UNC1999 is a UTX activator that enhances UTX demethylase activity by inhibiting the enzymatic activity of the EZH2 methyltransferase. By preventing H3K27 methylation, UNC1999 promotes the removal of methyl groups by UTX, leading to increased transcriptional activation of UTX target genes. The chemical's dual impact on EZH2 and UTX underscores its role as a UTX activator, providing a specific means to modulate UTX function within cellular pathways. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX-01294 is a UTX activator that enhances UTX demethylase activity by inhibiting the G9a histone methyltransferase. By preventing H3K9 methylation, BIX-01294 facilitates the removal of methyl groups by UTX from H3K27me3, leading to increased transcriptional activation of UTX target genes. The chemical's dual impact on G9a and UTX underscores its role as a UTX activator, providing a specific means to modulate UTX function within cellular pathways. | ||||||
OG-L002 | 1357302-64-7 | sc-478221 | 5 mg | $270.00 | ||
OG-L002 is a UTX activator that enhances UTX demethylase activity by blocking the binding of the UTX Jumonji C (JmjC) domain to its substrate. This disruption promotes the removal of methyl groups from H3K27me3, leading to increased transcriptional activation of UTX target genes. OG-L002's direct modulation of the JmjC domain underscores its role as a specific UTX activator, providing a focused approach for enhancing UTX function within cellular pathways. | ||||||