utrophin Antibody (3B6): sc-33699

Utrophin Antibody (3B6) is a mouse monoclonal IgG1 antibody that detects utrophin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Utrophin is a crucial structural protein that shares significant homology with dystrophin and plays a vital role in anchoring the cytoskeleton to the plasma membrane, particularly in muscle and brain tissues. Localization to the inner surface of the plasma membrane is essential for maintaining cellular integrity and facilitating communication between the cytoskeleton and the extracellular matrix. Notably, utrophin undergoes alternative splicing, which allows interaction with various proteins, contributing to functional versatility. Anti-utrophin antibody (3B6) serves as an invaluable tool for researchers investigating molecular mechanisms underlying muscular dystrophies, where utrophin upregulation has been shown to mitigate pathological effects associated with dystrophin absence, highlighting potential therapeutic applications.

The preferred utrophin antibody is utrophin Antibody (8A4): sc-33700.