UTP14C Antibody (H-1): sc-365603

UTP14C Antibody (H-1) is a mouse monoclonal IgM antibody that detects UTP14C of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-UTP14C antibody (H-1) is available as the non-conjugated form. UTP14C, also known as UTP14 or U3 small nucleolar ribonucleoprotein, is a 766 amino acid protein primarily localized in the nucleolus, where UTP14C plays a critical role in ribosome biogenesis. This nucleolar localization is essential as ribosomal RNA synthesis and assembly occur here, making UTP14C vital for ribosome production necessary for protein synthesis in all cells. During male meiosis, UTP14C is specifically required for proper sperm cell development, highlighting UTP14C′s importance in spermatogenesis. The UTP14C gene is located on human chromosome 13, a region containing over 400 genes, including those associated with significant health conditions. Understanding UTP14C′s function and localization not only reveals its role in reproductive biology but also emphasizes potential implications in various diseases, including infertility and certain genetic disorders.

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UTP14C Antibody (H-1) References:

1. An X-to-autosome retrogene is required for spermatogenesis in mice.  |  Bradley, J., et al. 2004. Nat Genet. 36: 872-6. PMID: 15258580
2. The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b.  |  Rohozinski, J. and Bishop, CE. 2004. Proc Natl Acad Sci U S A. 101: 11695-700. PMID: 15289605
3. UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man.  |  Rohozinski, J., et al. 2006. Biol Reprod. 74: 644-51. PMID: 16354793
4. Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle-stimulating hormone mutations.  |  Shetty, G., et al. 2006. Endocrinology. 147: 3563-70. PMID: 16627582
5. Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis.  |  Zhao, M., et al. 2007. Dev Biol. 304: 848-59. PMID: 17291484
6. Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.  |  Rohozinski, J., et al. 2009. PLoS One. 4: e5064. PMID: 19333399

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-UTP14C Antibody (H-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-UTP14C Antibody (H-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

UTP14C Antibody (H-1) Specifications

Alternate Product Name: UTP14C

Product Clone Name: H-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 679-711

Epitope Target: UTP14C

Epitope Species: human

Product Reactivity/Detection: UTP14C of human origin and UTP14A of mouse, rat and human origin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for UTP14C Antibody (H-1): P: Blocking Peptide