USPL1 Antibody (2F12): sc-293331
- USPL1 Antibody (2F12) is a mouse monoclonal IgG2a κ USPL1 antibody provided at 100 µg/ml
- raised against amino acids 975-1074 of USPL1 of human origin
- recommended for detection of USPL1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for USPL1 Antibody (2F12). This work is in progress.
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USPL1 Antibody (2F12) is a mouse monoclonal IgG2a kappa light chain antibody that detects the USPL1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-USPL1 antibody (2F12) is available as a non-conjugated isotype antibody. USPL1, or ubiquitin specific peptidase like 1, plays a crucial role in regulating protein degradation and cellular signaling pathways by removing ubiquitin moieties from target proteins, thereby influencing their stability and function. This activity is particularly important in cancer biology, as dysregulation of ubiquitin-mediated proteolysis can lead to accumulation of oncogenic proteins and contribute to tumorigenesis. USPL1 is encoded by a gene located on human chromosome 13, which houses several key tumor suppressor genes, including BRCA2 and RB1, both implicated in various cancers. Multiple alternatively spliced isoforms of USPL1 underscore functional diversity and potential involvement in different cellular processes. Understanding USPL1 and its interactions within the ubiquitin-proteasome system is essential for elucidating contributions to disease mechanisms and developing targeted therapeutic strategies.
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USPL1 Antibody (2F12) References:
- The DNA sequence and analysis of human chromosome 13. | Dunham, A., et al. 2004. Nature. 428: 522-8. PMID: 15057823
- UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man. | Rohozinski, J., et al. 2006. Biol Reprod. 74: 644-51. PMID: 16354793
- In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis. | O'Reilly, MK., et al. 2006. Biochemistry. 45: 9593-603. PMID: 16878994
- Non-disjunction of chromosome 13. | Bugge, M., et al. 2007. Hum Mol Genet. 16: 2004-10. PMID: 17584770
- The origin of trisomy 13. | Hall, HE., et al. 2007. Am J Med Genet A. 143A: 2242-8. PMID: 17853475
- Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture. | Hassler, M., et al. 2007. Mol Cell. 28: 371-85. PMID: 17996702
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
USPL1 Antibody (2F12) | sc-293331 | 100 µg/ml | $316.00 |