USP9X/Y Antibody (G-10): sc-373818

USP9X/Y Antibody (G-10) is a mouse monoclonal IgG1 antibody that detects USP9X in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). USP9X, also known as ubiquitin specific peptidase 9, X-linked, is a crucial member of the peptidase C19 family of ubiquitin proteases, consisting of 2,547 amino acids. This protein plays a vital role in the ubiquitin pathway, which is essential for regulating various intracellular processes, including signal transduction, transcriptional activation, and cell cycle progression. USP9X is predominantly located in the cytoplasm and nucleus, where USP9X is involved in the processing of ubiquitin precursors and ubiquitinated proteins, thereby preventing their degradation and maintaining protein turnover. Proper functioning of USP9X is particularly important as defects in USP9X gene are linked to Turner syndrome, a condition that affects female development and fertility, highlighting USP9X significance in reproductive biology. Additionally, USP9Y, a closely related protein, shares similar functions and is implicated in male infertility, further underscoring the importance of these ubiquitin-specific peptidases in both sexes. USP9X/Y (G-10) antibody is an invaluable tool for researchers studying the dynamics of protein regulation and the implications of ubiquitin signaling in various biological contexts.

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USP9X/Y Antibody (G-10) References:

1. Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.  |  Hall, NM., et al. 2003. Mamm Genome. 14: 437-47. PMID: 12925892
2. Targeting USP9X-AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma.  |  Zhang, FK., et al. 2022. Cell Mol Gastroenterol Hepatol. 14: 101-127. PMID: 35390516
3. USP9X Increased Tumor Angiogenesis in Mantle Cell Lymphoma by Upregulation of CCND1-Mediated SOX11.  |  Huang, G., et al. 2022. Mediterr J Hematol Infect Dis. 14: e2022048. PMID: 35865393
4. USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells.  |  Zhao, J., et al. 2023. Cell Death Dis. 14: 40. PMID: 36653359
5. KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle.  |  Chappell, DL., et al. 2023. J Virol. 97: e0176322. PMID: 36995092
6. USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities.  |  Perurena, N., et al. 2023. Cell Rep Med. 4: 101007. PMID: 37030295
7. Deubiquitinase USP9X loss sensitizes renal cancer cells to mTOR inhibition.  |  Roldán-Romero, JM., et al. 2023. Int J Cancer. 153: 1300-1312. PMID: 37260183
8. USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15.  |  Savio, MG., et al. 2023. Curr Biol. 33: 5533. PMID: 38113830
9. Abrogation of USP9X Is a Potential Strategy to Decrease PEG10 Levels and Impede Tumor Progression in Cutaneous T-Cell Lymphoma.  |  Xiong, S., et al. 2024. J Invest Dermatol. 144: 2778-2788.e9. PMID: 38677662
10. USP9X inhibits metastasis in pulmonary sarcomatoid carcinoma by regulating epithelial-mesenchymal transition, angiogenesis and immune infiltration.  |  Feng, Q., et al. 2024. Transl Oncol. 47: 101950. PMID: 38964032

The preferred USP9X/Y antibody is USP9X/Y Antibody (E-12): sc-365353.