USP52 Antibody (6A7): sc-517176

USP52 Antibody (6A7) is a mouse monoclonal IgG1 kappa light chain antibody that detects USP52 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-USP52 antibody (6A7) is available as the non-conjugated format. USP52, also known as PAN2, plays a crucial role in regulating mRNA stability and decay, which is vital for maintaining proper gene expression and cellular function. Located in both cytoplasm and nucleus, USP52 functions as a key component of the Pan nuclease complex, participating in the shortening of poly(A) tails of RNA molecules. This process is essential for mRNA degradation, influencing transcript turnover and overall control of protein synthesis within cells. Through modulation of mRNA decay, USP52 helps regulate various cellular processes, including signal transduction and cell cycle progression, making USP52 an important player in the ubiquitin pathway that governs numerous intracellular functions.

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USP52 Antibody (6A7) References:

1. Deubiquitinating enzymes: their diversity and emerging roles.  |  Chung, CH. and Baek, SH. 1999. Biochem Biophys Res Commun. 266: 633-40. PMID: 10603300
2. Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks.  |  Hammet, A., et al. 2002. J Biol Chem. 277: 22469-74. PMID: 11953437
3. A history of poly A sequences: from formation to factors to function.  |  Edmonds, M. 2002. Prog Nucleic Acid Res Mol Biol. 71: 285-389. PMID: 12102557
4. Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover.  |  Yamashita, A., et al. 2005. Nat Struct Mol Biol. 12: 1054-63. PMID: 16284618
5. Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells.  |  Zheng, D., et al. 2008. J Cell Biol. 182: 89-101. PMID: 18625844
6. The role of deadenylation in the degradation of unstable mRNAs in trypanosomes.  |  Schwede, A., et al. 2009. Nucleic Acids Res. 37: 5511-28. PMID: 19596809
7. Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps.  |  Chen, CY., et al. 2009. Nat Struct Mol Biol. 16: 1160-6. PMID: 19838187
8. The yeast Pan2 protein is required for poly(A)-binding protein-stimulated poly(A)-nuclease activity.  |  Boeck, R., et al. 1996. J Biol Chem. 271: 432-8. PMID: 8550599
9. Deubiquitinating enzymes: a new class of biological regulators.  |  D'Andrea, A. and Pellman, D. 1998. Crit Rev Biochem Mol Biol. 33: 337-52. PMID: 9827704

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-USP52 Antibody (6A7) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-USP52 Antibody (6A7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

USP52 Antibody (6A7) Specifications

Alternate Product Name: USP52

Product Clone Name: 6A7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1099-1198

Epitope Target: USP52

Epitope Species: human

Product Reactivity/Detection: USP52

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for USP52 Antibody (6A7): N/A