USP5 Antibody (1340CT704.170.140): sc-517374
- USP5 Antibody (1340CT704.170.140) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against a recombinant protein corresponding to USP5 of human origin
- recommended for detection of USP5 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for USP5 Antibody (1340CT704.170.140). This work is in progress.
USP5 Antibody (1340CT704.170.140) is a mouse monoclonal IgG1 antibody that detects USP5 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). USP5, also known as ubiquitin specific peptidase 5 or isopeptidase T, is a crucial 858 amino acid zinc-binding deubiquitinating enzyme that plays a significant role in the ubiquitin (Ub) pathway, which is essential for regulating various intracellular processes including signal transduction, transcriptional activation, and cell cycle progression. The structure of USP5 contains two UBA (ubiquitin-associated) domains and one UBP-type zinc finger, which are vital for interaction with ubiquitin and enzymatic activity. By disassembling unanchored polyubiquitin chains, USP5 helps maintain cellular homeostasis and modulates protein degradation, thereby influencing numerous signaling pathways and cellular functions. USP5′s ability to regulate protein stability and turnover underscores its importance in various physiological and pathological processes, making anti-USP5 antibody (1340CT704.170.140) an invaluable tool for researchers studying protein ubiquitination dynamics and implications in diseases such as cancer and neurodegeneration.
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USP5 Antibody (1340CT704.170.140) References:
- Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation. | Sun, HL., et al. 2020. Mol Cell. 80: 633-647.e7. PMID: 33217317
- Structure-Activity Relationship of USP5 Inhibitors. | Mann, MK., et al. 2021. J Med Chem. 64: 15017-15036. PMID: 34648286
- USP5 facilitates non-small cell lung cancer progression through stabilization of PD-L1. | Pan, J., et al. 2021. Cell Death Dis. 12: 1051. PMID: 34741014
- USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity. | Li, J., et al. 2022. Nat Commun. 13: 7799. PMID: 36528652
- METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression. | Xia, P., et al. 2023. Cancer Commun (Lond). 43: 338-364. PMID: 36602428
- A pan-cancer analysis of the role of USP5 in human cancers. | Yan, B., et al. 2023. Sci Rep. 13: 8972. PMID: 37268697
- PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression. | Peng, ZM., et al. 2024. Breast Cancer Res. 26: 10. PMID: 38217030
- The deubiquitinase USP5 promotes cholangiocarcinoma progression by stabilizing YBX1. | Ning, F., et al. 2024. Life Sci. 348: 122674. PMID: 38692507
- USP5 Promotes Ripretinib Resistance in Gastrointestinal Stromal Tumors by MDH2 Deubiquition. | Sun, H., et al. 2024. Adv Sci (Weinh). 11: e2401171. PMID: 38973363
- Deubiquitinase USP5 regulates RIPK1 driven pyroptosis in response to myocardial ischemic reperfusion injury. | Sun, W., et al. 2024. Cell Commun Signal. 22: 466. PMID: 39350285
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
USP5 Antibody (1340CT704.170.140) | sc-517374 | 100 µg/ml | $316.00 |