USP33 Antibody (1D7): sc-100632

USP33 Antibody (1D7) is a mouse monoclonal IgG1 kappa light chain antibody that detects the USP33 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). USP33 (1D7) antibody is available as a non-conjugated antibody. USP33, also known as ubiquitin specific peptidase 33 or VHL-interacting deubiquitinating enzyme 1, is a crucial 942 amino acid protein that plays a significant role in the ubiquitin-proteasome system, which is essential for regulating protein degradation and maintaining cellular homeostasis. USP33 is primarily located in the cytoplasm and nucleus, where USP33 functions as a deubiquitinating enzyme, removing ubiquitin moieties from target proteins and thus preventing their degradation by the proteasome. USP33′s ability to modulate the levels of ubiquitinated proteins is vital for various cellular processes, including signal transduction, transcriptional regulation, and cell cycle progression. Additionally, USP33 interacts with the von Hippel-Lindau (VHL) protein, which is involved in the regulation of hypoxia-inducible factors, further underscoring USP33′s importance in cellular responses to oxygen levels. The expression of three isoforms of USP33, resulting from alternative splicing, adds another layer of complexity to USP33′s regulatory functions, making USP33 a significant target for research in cancer and other diseases where the ubiquitin pathway is disrupted.

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USP33 Antibody (1D7) References:

1. Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein.  |  Li, Z., et al. 2002. J Biol Chem. 277: 4656-62. PMID: 11739384
2. Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.  |  Li, Z., et al. 2002. Biochem Biophys Res Commun. 294: 700-9. PMID: 12056827
3. Human and mouse proteases: a comparative genomic approach.  |  Puente, XS., et al. 2003. Nat Rev Genet. 4: 544-58. PMID: 12838346
4. Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.  |  Curcio-Morelli, C., et al. 2003. J Clin Invest. 112: 189-96. PMID: 12865408
5. Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects.  |  Bianco, AC. 2004. Arq Bras Endocrinol Metabol. 48: 16-24. PMID: 15611815
6. VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha.  |  Li, Z., et al. 2005. EMBO Rep. 6: 373-8. PMID: 15776016
7. A leukemia-enriched cDNA microarray platform identifies new transcripts with relevance to the biology of pediatric acute lymphoblastic leukemia.  |  De Pittà, C., et al. 2005. Haematologica. 90: 890-8. PMID: 15996926
8. Cellular and structural biology of the deiodinases.  |  Bianco, AC. and Larsen, PR. 2005. Thyroid. 15: 777-86. PMID: 16131321
9. The solution structure of the ZnF UBP domain of USP33/VDU1.  |  Allen, MD. and Bycroft, M. 2007. Protein Sci. 16: 2072-5. PMID: 17766394

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-USP33 Antibody (1D7) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-USP33 Antibody (1D7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

USP33 Antibody (1D7) Specifications

Alternate Product Name: USP33

Product Clone Name: 1D7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 327-427

Epitope Target: USP33

Epitope Species: human

Product Reactivity/Detection: USP33

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for USP33 Antibody (1D7): N/A