urotensin II Antibody (UII-13): sc-52299

Urotensin II Antibody (UII-13) is a mouse monoclonal IgG antibody that detects Urotensin II in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Urotensin II is a potent vasoactive peptide that plays a crucial role in cardiovascular regulation, primarily by inducing vasoconstriction and influencing blood pressure. This peptide is synthesized as a precursor and undergoes proteolytic cleavage to yield the active form, which consists of 11 amino acids in humans. The cyclic structure of Urotensin II is essential for biological activity, as this structure allows for specific receptor binding, particularly to the G protein-coupled receptor GPR14. This interaction triggers various intracellular signaling pathways that can lead to physiological responses such as vascular smooth muscle contraction and modulation of cardiac function. Urotensin II is predominantly found in vascular and cardiac tissues, including areas affected by coronary atheroma, highlighting Urotensin II′s importance in both normal physiology and pathological conditions. Research suggests that Urotensin II may function as an autocrine or paracrine hormone, contributing to ventricular hypertrophy development in response to chronic hypoxia, thereby underscoring Urotensin II′s potential role in cardiovascular diseases. Anti-Urotensin II antibody (UII-13) serves as an invaluable tool for researchers investigating cardiovascular regulation mechanisms and Urotensin II implications in health and disease.

The preferred urotensin II antibody is urotensin II Antibody (UII-9): sc-52301.