urotensin II Antibody (UII-9): sc-52301

Urotensin II Antibody (UII-9) is a mouse monoclonal IgG antibody that detects urotensin II protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-urotensin II antibody (UII-9) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important peptide. Urotensin II, a potent vasoconstrictor, plays a critical role in cardiovascular physiology and pathology, particularly in regulating blood pressure and cardiac function. This 11-amino acid peptide is derived from a precursor protein and remains highly conserved across species, with its cyclic structure being essential for biological activity. Urotensin II exists in both vascular and cardiac tissues, including significant presence in coronary atheroma, highlighting its importance in cardiovascular health. Urotensin II interacts with G protein-coupled receptor GPR14, which mediates effects on vascular smooth muscle contraction. Urotensin II may function as an autocrine and paracrine hormone, contributing to ventricular hypertrophy development in response to chronic hypoxia, thus underscoring its relevance in various cardiovascular diseases.

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urotensin II Antibody (UII-9) References:

1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.  |  Ames, RS., et al. 1999. Nature. 401: 282-6. PMID: 10499587
2. Effect of chronic hypoxia on contents of urotensin II and its functional receptors in rat myocardium.  |  Zhang, Y., et al. 2002. Heart Vessels. 16: 64-8. PMID: 11833844
3. Plasma concentration of urotensin II is raised in hypertension.  |  Cheung, BM., et al. 2004. J Hypertens. 22: 1341-4. PMID: 15201550
4. Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta.  |  Bousette, N., et al. 2004. Atherosclerosis. 176: 117-23. PMID: 15306183
5. Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart.  |  Russell, FD. and Molenaar, P. 2004. Cardiovasc Res. 63: 673-81. PMID: 15306223
6. Biochemical characterization and immunohistochemical localization of urotensin II in the human brainstem and spinal cord.  |  Chartrel, N., et al. 2004. J Neurochem. 91: 110-8. PMID: 15379892
7. Neurohormones from fish tails: the caudal neurosecretory system. I. 'Urophysiology' and the caudal neurosecretory system of fishes.  |  Bern, HA., et al. 1985. Recent Prog Horm Res. 41: 533-52. PMID: 2864726
8. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord.  |  Coulouarn, Y., et al. 1998. Proc Natl Acad Sci U S A. 95: 15803-8. PMID: 9861051

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-urotensin II Antibody (UII-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-urotensin II Antibody (UII-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

urotensin II Antibody (UII-9) Specifications

Alternate Product Name: urotensin II

Product Clone Name: UII-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG

Amino Acids:

Epitope Target: urotensin II

Epitope Species: human

Product Reactivity/Detection: urotensin II

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for urotensin II Antibody (UII-9): N/A