urocortin II Antibody (A): sc-517452
- urocortin II Antibody (A) is a mouse monoclonal IgG2b λ urocortin II antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 20-112 of urocortin II of human origin
- recommended for detection of urocortin II of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for urocortin II Antibody (A). This work is in progress.
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Urocortin II Antibody (A) is a mouse monoclonal IgG2b antibody that detects urocortin II protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-urocortin II antibody (A) is available as the non-conjugated format. Urocortin II, a member of the corticotropin-releasing hormone (CRH) family, plays a crucial role in the regulation of stress responses and appetite. Urocortin II is primarily expressed in the brain, particularly in the midbrain, where distinct expression patterns suggest significant influence on behaviors such as feeding, anxiety, and auditory processing. Urocortin II′s ability to bind with high affinity to CRH receptors allows stimulation of adrenocorticotropic hormone (ACTH) release from the anterior pituitary, highlighting importance in neuroendocrine response to stress. Additionally, urocortin II is encoded by a gene located on human chromosome 2, and interactions with other urocortins, such as urocortin I and III, further underscore a role in mediating stress-coping responses. Urocortin III specifically binds to the CRF type 2 receptor, which is involved in various physiological processes. Expression of urocortin I and III in the human heart, pituitary gland, adrenal gland, gastrointestinal tract, ovary, spleen, brain, and kidney indicates widespread impact on human health and disease.
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urocortin II Antibody (A) References:
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- Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the 'elimination test'. | Darai, E., et al. 2005. Genomics. 86: 1-12. PMID: 15913951
- The DNA sequence, annotation and analysis of human chromosome 3. | Muzny, DM., et al. 2006. Nature. 440: 1194-8. PMID: 16641997
- Establishment and characterization of two uveal melanoma cell lines derived from tumors with loss of one chromosome 3. | Nareyeck, G., et al. 2006. Exp Eye Res. 83: 858-64. PMID: 16750193
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
urocortin II Antibody (A) | sc-517452 | 100 µg/ml | $316.00 |