uricase Antibody (C-11): sc-166214
- uricase Antibody (C-11) is a mouse monoclonal IgG2a λ uricase antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1-303 of uricase of mouse origin
- uricase Antibody (C-11) is recommended for detection of uricase of mouse and rat origin by WB, IP, IF and ELISA
- Anti-uricase Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to biotin for WB, IHC(P) and ELISA
- m-IgG2a BP-HRP and m-IgGλ BP-HRP are the preferred secondary detection reagents for uricase Antibody (C-11) for WB applications. These reagents are now offered in bundles with uricase Antibody (C-11) (see ordering information below).
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SEE ALSO...
uricase Antibody (C-11) is a mouse monoclonal IgG2a λ light chain antibody that detects uricase protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). uricase Antibody (C-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Uricase, also known as urate oxidase, plays a crucial role in purine metabolism by catalyzing the oxidation of uric acid to allantoin, a more soluble compound that can be easily excreted from the body. This enzymatic function is particularly important as elevated levels of uric acid can lead to conditions such as gout and kidney stones. In most mammals, uricase is predominantly found in the liver, localized within peroxisomes, and exists as a tetramer, which is essential for enzymatic activity. Interestingly, humans and certain primates lack this enzyme due to a genetic mutation that occurred relatively recently in evolutionary terms, which has implications for the management of uric acid levels in these species. The gene encoding uricase is located on human chromosome 1p22, and understanding its structure and function can provide insights into metabolic disorders associated with purine metabolism, such as Lesch-Nyhan syndrome, which is linked to deficiencies in the purine salvage pathway.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
uricase Antibody (C-11) References:
- Localization of the human urate oxidase gene (UOX) to 1p22. | Yeldandi, AV., et al. 1992. Cytogenet Cell Genet. 61: 121-2. PMID: 1395718
- Rasburicase therapy in acute hyperuricemia and renal dysfunction. | Ronco, C., et al. 2005. Contrib Nephrol. 147: 115-123. PMID: 15604611
- Urate oxidase: primary structure and evolutionary implications. | Wu, XW., et al. 1989. Proc Natl Acad Sci U S A. 86: 9412-6. PMID: 2594778
- A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. | Kuehn, MR., et al. Nature. 326: 295-8. PMID: 3029599
- HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. | Hooper, M., et al. Nature. 326: 292-5. PMID: 3821905
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
uricase Antibody (C-11) | sc-166214 | 200 µg/ml | $316.00 | |||
uricase Antibody (C-11): m-IgGλ BP-HRP Bundle | sc-521535 | 200 µg Ab, 40 µg BP | $354.00 | |||
uricase Antibody (C-11): m-IgG2a BP-HRP Bundle | sc-546234 | 200 µg Ab; 10 µg BP | $354.00 | |||
uricase Antibody (C-11) AC | sc-166214 AC | 500 µg/ml, 25% agarose | $416.00 | |||
uricase Antibody (C-11) HRP | sc-166214 HRP | 200 µg/ml | $316.00 | |||
uricase Antibody (C-11) FITC | sc-166214 FITC | 200 µg/ml | $330.00 | |||
uricase Antibody (C-11) PE | sc-166214 PE | 200 µg/ml | $343.00 | |||
uricase Antibody (C-11) Alexa Fluor® 488 | sc-166214 AF488 | 200 µg/ml | $357.00 | |||
uricase Antibody (C-11) Alexa Fluor® 546 | sc-166214 AF546 | 200 µg/ml | $357.00 | |||
uricase Antibody (C-11) Alexa Fluor® 594 | sc-166214 AF594 | 200 µg/ml | $357.00 | |||
uricase Antibody (C-11) Alexa Fluor® 647 | sc-166214 AF647 | 200 µg/ml | $357.00 | |||
uricase Antibody (C-11) Alexa Fluor® 680 | sc-166214 AF680 | 200 µg/ml | $357.00 | |||
uricase Antibody (C-11) Alexa Fluor® 790 | sc-166214 AF790 | 200 µg/ml | $357.00 | |||
uricase Antibody (C-11) B | sc-166214 B | 200 µg/ml | $320.00 |