UNKL Antibody (F-8): sc-398716

UNKL Antibody (F-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects UNKL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-UNKL antibody (F-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. UNKL protein, also known as unkempt homolog (Drosophila)-like, RING finger protein unkempt-like, putative E3 ubiquitin-protein ligase UNKL, ZC3H5L, or ZC3HDC5L, is a 680 amino acid protein that exists as six alternatively spliced isoforms and belongs to the unkempt family. UNKL includes four C3H1-type zinc fingers and one RING-type zinc finger, which are critical for functioning as an E3 ubiquitin ligase, facilitating the ubiquitination process that tags proteins for degradation. This post-translational modification maintains cellular homeostasis, regulates protein levels, and controls various cellular processes, including cell cycle progression and response to stress. UNKL gene is located on human chromosome 16, a region associated with several genetic disorders, including giant axonal neuropathy and Rubinstein-Taybi syndrome, highlighting UNKL′s importance in both normal physiology and disease states.

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UNKL Antibody (F-8) References:

1. The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy.  |  Bomont, P., et al. 2000. Nat Genet. 26: 370-4. PMID: 11062483
2. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.  |  Daniels, RJ., et al. 2001. Hum Mol Genet. 10: 339-52. PMID: 11157797
3. Giant axonal neuropathy (GAN): case report and two novel mutations in the gigaxonin gene.  |  Kuhlenbäumer, G., et al. 2002. Neurology. 58: 1273-6. PMID: 11971098
4. Genetics of inflammatory bowel disease: progress and prospects.  |  Mathew, CG. and Lewis, CM. 2004. Hum Mol Genet. 13 Spec No 1: R161-8. PMID: 14764625
5. Advances in the genetics of inflammatory bowel disease.  |  Cho, JH. 2004. Curr Gastroenterol Rep. 6: 467-73. PMID: 15527676
6. The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt.  |  Lorès, P., et al. 2010. FEBS J. 277: 1453-64. PMID: 20148946
7. Unkempt is negatively regulated by mTOR and uncouples neuronal differentiation from growth control.  |  Avet-Rochex, A., et al. 2014. PLoS Genet. 10: e1004624. PMID: 25210733
8. Identification of key genes for hypertrophic cardiomyopathy using integrated network analysis of differential lncRNA and gene expression.  |  Cao, J. and Yuan, L. 2022. Front Cardiovasc Med. 9: 946229. PMID: 35990977
9. Genome-wide analyses reveal the regulatory roles of DNA methylation-regulated alternative promoter transcripts in breast cancer.  |  Song, Y., et al. 2024. Hum Genet. 143: 385-399. PMID: 38502355
10. The Rubinstein-Taybi syndrome: occurrence in two sets of identical twins.  |  Baraitser, M. and Preece, MA. 1983. Clin Genet. 23: 318-20. PMID: 6682729
11. Rubinstein-Taybi syndrome caused by submicroscopic deletions within 16p13.3.  |  Breuning, MH., et al. 1993. Am J Hum Genet. 52: 249-54. PMID: 8430691

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-UNKL Antibody (F-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-UNKL Antibody (F-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

UNKL Antibody (F-8) Specifications

Alternate Product Name: UNKL

Product Clone Name: F-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 586-680

Epitope Target: UNKL

Epitope Species: human

Product Reactivity/Detection: UNKL

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for UNKL Antibody (F-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin