UNC45A Antibody (F-7): sc-390231
- UNC45A Antibody (F-7) is a mouse monoclonal mouse IgM κ κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 923-944 at the C-terminus of UNC45A of human origin
- recommended for detection of UNC45A of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for UNC45A Antibody (F-7). This work is in progress.
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UNC45A Antibody (F-7) is a mouse monoclonal IgM antibody that detects UNC45A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UNC45A, also known as SMAP1 or GCUNC45, is a 944 amino acid protein that plays a crucial role as a chaperone for heat shock protein 90 (HSP90), facilitating HSP90′s interaction with the progesterone receptor (PR). This interaction is vital for PR′s proper functioning, which is essential in various physiological processes, including reproductive functions and cellular responses to stress. UNC45A is necessary for the correct folding of myosin, a key protein involved in muscle contraction, and is required for normal myotube formation during muscle cell development, highlighting UNC45A′s importance in muscle formation and regeneration. UNC45A expression is notably observed in tissues such as the spinal cord, bone marrow, peripheral blood leukocytes, trachea, stomach, and adrenal gland. UNC45A overexpression has been linked to increased cell proliferation and motility, particularly in ovarian cancer, suggesting UNC45A′s potential role in tumorigenesis. Multiple isoforms of UNC45A, resulting from alternative splicing events, add another layer of complexity to UNC45A′s function and regulation in cellular processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UNC45A Antibody (F-7) | sc-390231 | 200 µg/ml | $322.00 | |||
UNC45A (F-7) Neutralizing Peptide | sc-390231 P | 100 µg/0.5 ml | $69.00 |