Unc18-2 Antibody (B-2): sc-376639

Unc18-2 Antibody (B-2) is a mouse monoclonal IgM antibody that detects Unc18-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Unc18-2 Antibody (B-2) is available in a non-conjugated form, providing flexibility for various experimental needs. Unc18-2, part of the Unc18 family of proteins, plays a crucial role in the regulation of exocytosis by acting as a chaperone that prevents syntaxin from interacting prematurely with its cognate SNARE proteins. This regulation is vital for maintaining proper neurotransmitter release and cellular communication. Unc18-2 is predominantly localized at the apical plasma membrane of epithelial cells, including those in the intestinal and renal systems, where Unc18-2 co-localizes with Syntaxin 3. This localization is essential for the precise control of vesicle trafficking and secretion in these tissues, highlighting Unc18-2′s importance in physiological processes such as nutrient absorption and fluid balance. Unc18-2′s presence in various cell types, including mast cells and platelets, further underscores its significance in diverse biological functions.

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Unc18-2 Antibody (B-2) References:

1. Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis.  |  Barclay, JW., et al. 2003. J Biol Chem. 278: 10538-45. PMID: 12519779
2. A role for Sec1/Munc18 proteins in platelet exocytosis.  |  Schraw, TD., et al. 2003. Biochem J. 374: 207-17. PMID: 12773094
3. Alcoholic chronic pancreatitis involves displacement of Munc18c from the pancreatic acinar basal membrane surface.  |  Gaisano, HY., et al. 2004. Pancreas. 28: 395-400. PMID: 15097857
4. Syntaxin/Munc18 interactions in the late events during vesicle fusion and release in exocytosis.  |  Graham, ME., et al. 2004. J Biol Chem. 279: 32751-60. PMID: 15175344
5. Regulation of syntaxin1A-munc18 complex for SNARE pairing in HEK293 cells.  |  Gladycheva, SE., et al. 2004. J Physiol. 558: 857-71. PMID: 15218059
6. Fluorescence resonance energy transfer reports properties of syntaxin1a interaction with Munc18-1 in vivo.  |  Liu, J., et al. 2004. J Biol Chem. 279: 55924-36. PMID: 15489225
7. Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.  |  Ciufo, LF., et al. 2005. Mol Biol Cell. 16: 470-82. PMID: 15563604
8. Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression.  |  Fu, J., et al. 2005. J Biol Chem. 280: 3178-84. PMID: 15576373
9. Expression and transcriptional regulation of Munc18 isoforms in mast cells.  |  Nigam, R., et al. 2005. Biochim Biophys Acta. 1728: 77-83. PMID: 15777698

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Unc18-2 Antibody (B-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Unc18-2 Antibody (B-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Unc18-2 Antibody (B-2) Specifications

Alternate Product Name: Unc18-2

Product Clone Name: B-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 481-519

Epitope Target: Unc18-2

Epitope Species: human

Product Reactivity/Detection: Unc18-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Unc18-2 Antibody (B-2): P: Blocking Peptide