uMtCK Antibody (C-8): sc-374080
- uMtCK Antibody (C-8) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 51-87 within an internal region of uMtCK of human origin
- recommended for detection of uMtCK of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for uMtCK Antibody (C-8) for WB applications. These reagents are now offered in bundles with uMtCK Antibody (C-8) (see ordering information below).
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uMtCK Antibody (C-8) is a mouse monoclonal IgG1 antibody that detects uMtCK in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). uMtCK, or human cytoplasmic CK-Mitochondrial, is a 416 amino acid isoform of creatine kinase that plays a crucial role in cellular energy metabolism, particularly within the mitochondria. uMtCK maintains ATP levels during periods of high energy demand, which is vital for the proper functioning of various tissues, including cardiac and skeletal muscle, as well as neurons. uMtCK localization in the mitochondria allows for rapid ATP regeneration in close proximity to energy consumption sites, supporting processes such as muscle contraction and neurotransmission. uMtCK also regulates calcium homeostasis, which is critical for cellular signaling and overall cellular health. anti-uMtCK antibody (C-8) serves as an invaluable tool for researchers studying energy metabolism and mitochondrial function in various biological contexts.
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uMtCK Antibody (C-8) References:
- Crystal structure of human ubiquitous mitochondrial creatine kinase. | Eder, M., et al. 2000. Proteins. 39: 216-25. PMID: 10737943
- Hodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis. | Kornacker, M., et al. 2001. Int J Cancer. 94: 513-9. PMID: 11745437
- Stabilization of ubiquitous mitochondrial creatine kinase preprotein by APP family proteins. | Li, X., et al. 2006. Mol Cell Neurosci. 31: 263-72. PMID: 16260146
- Ubiquitous mitochondrial creatine kinase downregulated in oral squamous cell carcinoma. | Onda, T., et al. 2006. Br J Cancer. 94: 698-709. PMID: 16479256
- Macroenzyme creatine kinase (CK) type 2 in HIV-infected patients is significantly associated with TDF and consists of ubiquitous mitochondrial CK. | Schmid, H., et al. 2006. Antivir Ther. 11: 1071-80. PMID: 17302377
- Ubiquitous mitochondrial creatine kinase is overexpressed in the conditioned medium and the extract of LNCaP lineaged androgen independent cell lines and facilitates prostate cancer progression. | Pang, B., et al. 2009. Prostate. 69: 1176-87. PMID: 19415690
- Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes. | Haas, RC. and Strauss, AW. 1990. J Biol Chem. 265: 6921-7. PMID: 2324105
- Mice deficient in ubiquitous mitochondrial creatine kinase are viable and fertile. | Steeghs, K., et al. 1995. Biochim Biophys Acta. 1230: 130-8. PMID: 7619831
- Developmental expression of sarcomeric and ubiquitous mitochondrial creatine kinase is tissue-specific. | Payne, RM. and Strauss, AW. 1994. Biochim Biophys Acta. 1219: 33-8. PMID: 8086475
- Inhibition of ubiquitous mitochondrial creatine kinase expression in HeLa cells by an antisense oligodeoxynucleotide. | Enjolras, N. and Godinot, C. 1997. Mol Cell Biochem. 167: 113-25. PMID: 9059988
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
uMtCK Antibody (C-8) | sc-374080 | 200 µg/ml | $322.00 | |||
uMtCK Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-535378 | 200 µg Ab; 40 µg BP | $361.00 | |||
uMtCK Antibody (C-8): m-IgG1 BP-HRP Bundle | sc-538883 | 200 µg Ab; 20 µg BP | $361.00 | |||
uMtCK (C-8) Neutralizing Peptide | sc-374080 P | 100 µg/0.5 ml | $69.00 |