UMPS Antibody (A-9): sc-398086

UMPS Antibody (A-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects uridine 5′-monophosphate synthase (UMPS) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UMPS (A-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. UMPS plays a crucial role in the pyrimidine biosynthetic pathway by catalyzing the final two steps, which are essential for the synthesis of nucleotides necessary for DNA and RNA production. In eukaryotes, UMPS uniquely combines the activities of orotate phosphoribosyltransferase and orotidine-5′-monophosphate decarboxylase into a single protein, a feature that enhances the stability of catalytic centers, particularly important given the low molar concentration in mammalian cells. Disruption of UMPS activity can lead to hereditary orotic aciduria, a rare genetic disorder that manifests as growth retardation, anemia, and increased urinary excretion of orotic acid. Additionally, two isoforms of UMPS arise from alternative splicing, which may have implications for functional diversity and regulation in different tissues.

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UMPS Antibody (A-9) References:

1. The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice.  |  Reisner, M., et al. 2004. Toxicol Sci. 82: 620-7. PMID: 15342955
2. Pseudo-merohedral twinning in monoclinic crystals of human orotidine-5'-monophosphate decarboxylase.  |  Wittmann, JG. and Rudolph, MG. 2007. Acta Crystallogr D Biol Crystallogr. 63: 744-9. PMID: 17505114
3. Orotic acid excretion and arginine metabolism.  |  Brosnan, ME. and Brosnan, JT. 2007. J Nutr. 137: 1656S-1661S. PMID: 17513443
4. Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design.  |  Wittmann, JG., et al. 2008. Structure. 16: 82-92. PMID: 18184586
5. Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase.  |  Yablonski, MJ., et al. 1996. J Biol Chem. 271: 10704-8. PMID: 8631878
6. Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families.  |  Suchi, M., et al. 1997. Am J Hum Genet. 60: 525-39. PMID: 9042911

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-UMPS Antibody (A-9) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-UMPS Antibody (A-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

UMPS Antibody (A-9) Specifications

Alternate Product Name: UMPS

Product Clone Name: A-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 208-445

Epitope Target: UMPS

Epitope Species: human

Product Reactivity/Detection: UMPS

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for UMPS Antibody (A-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin