ULBP2 Antibody (6F6): sc-53135

ULBP2 Antibody (6F6) is a mouse monoclonal IgM antibody that detects ULBP2 protein of human origin by immunoprecipitation (IP) and immunofluorescence (IF). Anti-ULBP2 antibody (6F6) is available as the non-conjugated format. ULBP2, a member of the UL16 binding protein family, plays a crucial role in immune response regulation by acting as a ligand for the activating receptor NKG2D/DAP10, which is essential for the activation of natural killer (NK) cells and CD8+ T cells. The interaction between ULBP2 and NKG2D triggers a cascade of immune responses, including the secretion of cytokines such as interferon-gamma, which is vital for the body′s defense against tumors and viral infections. Additionally, ULBP2 is involved in the modulation of immune cell activity, influencing the balance between immune activation and tolerance. Understanding ULBP2 function is important for developing therapeutic strategies aimed at enhancing anti-tumor immunity and improving responses to immunotherapy.

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ULBP2 Antibody (6F6) References:

1. Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity.  |  Dunn, C., et al. 2003. J Exp Med. 197: 1427-39. PMID: 12782710
2. Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein.  |  Rölle, A., et al. 2003. J Immunol. 171: 902-8. PMID: 12847260
3. NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity.  |  Maccalli, C., et al. 2003. Eur J Immunol. 33: 2033-43. PMID: 12884870
4. Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid.  |  Poggi, A., et al. 2004. Cancer Res. 64: 9172-9. PMID: 15604289
5. Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias.  |  Nowbakht, P., et al. 2005. Blood. 105: 3615-22. PMID: 15657183
6. Divergence and diversity of ULBP2 genes in rhesus and cynomolgus macaques.  |  Naruse, TK., et al. 2014. Immunogenetics. 66: 161-70. PMID: 24469065
7. The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway.  |  Uhlenbrock, F., et al. 2014. J Immunol. 193: 1654-65. PMID: 25024379
8. PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60.  |  Leung, WH., et al. 2015. J Immunol. 194: 2930-41. PMID: 25687758
9. Fumarate Upregulates Surface Expression of ULBP2/ULBP5 by Scavenging Glutathione Antioxidant Capacity.  |  Høgh, RI., et al. 2020. J Immunol. 204: 1746-1759. PMID: 32144161
10. An Immunosensor for the Detection of ULBP2 Biomarker.  |  Yang, WC., et al. 2020. Micromachines (Basel). 11: PMID: 32503144
11. An immune-related prognostic gene ULBP2 is correlated with immunosuppressive tumor microenvironment and immunotherapy in breast cancer.  |  Feng, R., et al. 2024. Heliyon. 10: e23687. PMID: 38205308
12. ULBP2 promotes progression of head and neck squamous cell carcinoma by modulating MAPK signaling pathway.  |  Xu, W., et al. 2024. J Stomatol Oral Maxillofac Surg. 102204. PMID: 39706260

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ULBP2 Antibody (6F6) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-ULBP2 Antibody (6F6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ULBP2 Antibody (6F6) Specifications

Alternate Product Name: ULBP2

Product Clone Name: 6F6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: ULBP2

Epitope Species: human

Product Reactivity/Detection: ULBP2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IP, IF

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for ULBP2 Antibody (6F6): L: Azide-Free