ULBP1 Antibody (3F1): sc-53131

ULBP1 Antibody (3F1) is a mouse monoclonal IgM antibody that detects ULBP1 protein of human origin by immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-ULBP1 antibody (3F1) is available as the non-conjugated format. ULBP1, a member of the UL16 binding protein family, plays a crucial role in the immune response by acting as a ligand for the activating receptor NKG2D/DAP10, which is essential for the activation of natural killer (NK) cells and CD8+ T cells. This interaction triggers the secretion of pro-inflammatory cytokines, including interferon-gamma, and promotes the lysis of tumor cells, highlighting ULBP1′s importance in immune surveillance and tumor immunology. ULBP1 is primarily located on the surface of stressed or transformed cells, where immune cells can recognize ULBP1, thus facilitating the elimination of potentially harmful cells. Additionally, ULBP1 is glycosylated, which can influence stability and interaction with receptors, further underscoring ULBP1′s significance in modulating immune responses. ULBP1′s ability to stimulate cytokine production and activate various signaling pathways, such as the Janus kinase 2 and phosphatidylinositol 3-kinase/Akt pathways, makes ULBP1 a vital component in the orchestration of immune responses against infections and tumors.

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ULBP1 Antibody (3F1) References:

1. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.  |  Cosman, D., et al. 2001. Immunity. 14: 123-33. PMID: 11239445
2. ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells.  |  Kubin, M., et al. 2001. Eur J Immunol. 31: 1428-37. PMID: 11465099
3. UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.  |  Sutherland, CL., et al. 2002. J Immunol. 168: 671-9. PMID: 11777960
4. Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein.  |  Rölle, A., et al. 2003. J Immunol. 171: 902-8. PMID: 12847260
5. Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.  |  Eleme, K., et al. 2004. J Exp Med. 199: 1005-10. PMID: 15051759
6. UL16 binding proteins.  |  Cao, W. and He, W. 2004. Immunobiology. 209: 283-90. PMID: 15518340
7. Immunoselection by natural killer cells of PIGA mutant cells missing stress-inducible ULBP.  |  Hanaoka, N., et al. 2006. Blood. 107: 1184-91. PMID: 16195329
8. Expression of the NKG2D ligand UL16 binding protein-1 (ULBP-1) on dendritic cells.  |  Schrama, D., et al. 2006. Eur J Immunol. 36: 65-72. PMID: 16342232

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ULBP1 Antibody (3F1) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-ULBP1 Antibody (3F1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ULBP1 Antibody (3F1) Specifications

Alternate Product Name: ULBP1

Product Clone Name: 3F1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: ULBP1

Epitope Species: human

Product Reactivity/Detection: ULBP1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for ULBP1 Antibody (3F1): L: Azide-Free