UHRF1 Antibody (C-9): sc-365391
- UHRF1 Antibody (C-9) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 239-262 within an internal region of UHRF1 of human origin
- recommended for detection of UHRF1 of mouse, rat and human origin by WB, IP, IF and ELISA
- See UHRF1 (H-8): sc-373750 for UHRF1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for UHRF1 Antibody (C-9) for WB applications. This reagent is now offered in a bundle with UHRF1 Antibody (C-9) (see ordering information below).
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UHRF1 Antibody (C-9) is a mouse monoclonal IgG2a antibody that detects UHRF1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UHRF1, also known as Np95, ICBP90, or RNF106, is a crucial transcription and cell cycle regulator that belongs to the RING-finger type E3 ubiquitin ligase subfamily. UHRF1 is primarily localized in the nucleus, where anti-UHRF1 antibody (C-9) reveals its role in cellular proliferation by functioning as an E3 ubiquitin-protein ligase. UHRF1 facilitates the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to target proteins, marking them for degradation, which is essential for maintaining cellular homeostasis and regulating the cell cycle. Additionally, UHRF1 interacts directly with Dnmt1, a maintenance DNA methyltransferase, ensuring stable association with chromatin, which is critical for the regulation of gene expression and epigenetic inheritance. Overexpression of UHRF1 in various cancer cells highlights potential involvement in carcinogenesis, making UHRF1 (C-9) antibody an invaluable tool for researchers studying cell cycle regulation and ubiquitination in cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UHRF1 Antibody (C-9) | sc-365391 | 200 µg/ml | $322.00 | |||
UHRF1 Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-540335 | 200 µg Ab; 10 µg BP | $361.00 | |||
UHRF1 (C-9) Neutralizing Peptide | sc-365391 P | 100 µg/0.5 ml | $69.00 |