UHRF1 Antibody (28): sc-136264
- UHRF1 Antibody (28) is a mouse monoclonal IgG2a, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 199-298 of UHRF1 of human origin
- recommended for detection of UHRF1 of human origin by WBIP
- See UHRF1 (H-8): sc-373750 for UHRF1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for UHRF1 Antibody (28). This work is in progress.
QUICK LINKS
SEE ALSO...
UHRF1 Antibody (28) is a mouse monoclonal IgG2a antibody that detects UHRF1 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). UHRF1, also known as Np95, ICBP90, or RNF106, is a crucial transcription and cell cycle regulator that belongs to the RING-finger type E3 ubiquitin ligase subfamily. UHRF1 is predominantly localized in the nucleus, where UHRF1 plays a vital role in cellular proliferation by functioning as an E3 ubiquitin-protein ligase. UHRF1 facilitates the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to target proteins, marking them for degradation, which is essential for maintaining cellular homeostasis and regulating the cell cycle. Additionally, UHRF1 directly interacts with Dnmt1, a maintenance DNA methyltransferase, ensuring stable association with chromatin, which is critical for proper regulation of gene expression and epigenetic inheritance. The overexpression of UHRF1 in cancer cells highlights UHRF1′s potential involvement in carcinogenesis, making UHRF1 a significant target for research in cancer biology. Anti-UHRF1 antibody (28) is an invaluable tool for scientists studying the mechanisms of ubiquitination and its implications in various diseases, particularly cancer.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UHRF1 Antibody (28) | sc-136264 | 50 µg/0.5 ml | $316.00 |