UCH-L1 Antibody (13C4): sc-58594
- UCH-L1 Antibody (13C4) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 200 µg/ml
- raised against native UCH-L1 protein of human origin
- recommended for detection of UCH-L1 on neuronal cell bodies and axons in the CNS and periphery, small nerve fibers in peripheral tissues, neuroendocrine cells in the pituitary, thyroid, pancreas and tumors of the DNES of mouse, rat and human origin by WB, IP, IF and IHC(P); also recommended for detection of UCH-L1 in human adult gut
- m-IgGκ BP-HRP is the preferred secondary detection reagent for UCH-L1 Antibody (13C4) for WB and IHC(P) applications. This reagent is now offered in a bundle with UCH-L1 Antibody (13C4) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
UCH-L1 Antibody (13C4) is a mouse monoclonal IgG2a antibody that detects UCH-L1 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. UCH-L1, or ubiquitin C-terminal hydrolase L1, plays a crucial role in the ubiquitin-proteasome system by hydrolyzing ubiquitin adducts to release free ubiquitin, which is essential for protein degradation and cellular homeostasis. UCH-L1 is predominantly expressed in neurons and neuroendocrine cells, with significant localization in the substantia nigra, an area critically involved in motor control. The presence of UCH-L1 in Lewy bodies, which are pathological hallmarks of Parkinson′s disease, underscores its importance in neurodegenerative processes. UCH-L1 constitutes about 1-2% of total soluble brain protein, highlighting its abundance and potential as a biomarker for neurodegenerative disorders. The gene encoding UCH-L1 is located on human chromosome 4p13, and its structural similarity to UCH-L3, which shares 54% identity, suggests a conserved function within the ubiquitin pathway. Anti-UCH-L1 antibody (13C4) is an invaluable tool for researchers investigating the role of ubiquitin-related processes in neurobiology and disease.
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UCH-L1 Antibody (13C4) References:
- The functions of UCH-L1 and its relation to neurodegenerative diseases. | Setsuie, R. and Wada, K. 2007. Neurochem Int. 51: 105-11. PMID: 17586089
- Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders. | Lee, YC. and Hsu, SD. 2017. Curr Protein Pept Sci. 18: 733-745. PMID: 26899237
- Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury. | Papa, L., et al. 2016. JAMA Neurol. 73: 551-60. PMID: 27018834
- Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries. | Wang, KK., et al. 2017. Expert Opin Ther Targets. 21: 627-638. PMID: 28434268
- Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in Prediction of Computed Tomography Findings in Traumatic Brain Injury; a Meta-Analysis. | Ramezani, F., et al. 2018. Emerg (Tehran). 6: e62. PMID: 30788389
- S100B, GFAP, UCH-L1 and NSE as predictors of abnormalities on CT imaging following mild traumatic brain injury: a systematic review and meta-analysis of diagnostic test accuracy. | Amoo, M., et al. 2022. Neurosurg Rev. 45: 1171-1193. PMID: 34709508
- UCH-L1 and UCH-L3 regulate the cancer stem cell-like properties through PI3 K/Akt signaling pathway in prostate cancer cells. | Lee, JE., et al. 2021. Anim Cells Syst (Seoul). 25: 312-322. PMID: 34745437
- Prognostic value of day-of-injury plasma GFAP and UCH-L1 concentrations for predicting functional recovery after traumatic brain injury in patients from the US TRACK-TBI cohort: an observational cohort study. | Korley, FK., et al. 2022. Lancet Neurol. 21: 803-813. PMID: 35963263
- Dysfunctional UCH-L1 inhibits proteostasis. | Wang, M. 2023. Nat Rev Nephrol. 19: 424. PMID: 37258710
- Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia. | Liang, Z., et al. 2024. Cell Rep. 43: 114152. PMID: 38669140
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UCH-L1 Antibody (13C4) | sc-58594 | 200 µg/ml | $322.00 | |||
UCH-L1 Antibody (13C4): m-IgGκ BP-HRP Bundle | sc-521055 | 200 µg Ab, 40 µg BP | $361.00 |