Ubr4 Antibody (21-Y): sc-100615

Ubr4 Antibody (21-Y) is a mouse monoclonal IgG2b kappa light chain antibody that detects Ubr4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Ubr4 antibody (21-Y) is available as the non-conjugated form. Ubr4, also known as ubiquitin protein ligase E3 component n-recognin 4, p600, ZUBR1, or RBAF600, is a 5,183 amino acid multi-pass membrane protein that plays a crucial role in cellular processes by localizing at the edges of membrane structures involved in actin motility. Ubr4 functions primarily as an E3 ubiquitin-protein ligase, recognizing and binding to proteins with specific N-terminal residues, which tags them for ubiquitination and subsequent degradation, thus regulating protein turnover and maintaining cellular homeostasis. Ubr4 interacts with Clathrin, forming meshwork structures essential for cytoskeletal organization and morphogenesis, and contains one Ubr-type zinc finger that may be involved in Integrin-mediated signaling pathways. Notably, Ubr4 has six isoforms resulting from alternative splicing, which may contribute to diverse functional roles in different cellular contexts.

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Ubr4 Antibody (21-Y) References:

1. A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.  |  Tasaki, T., et al. 2005. Mol Cell Biol. 25: 7120-36. PMID: 16055722
2. Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600.  |  Huh, KW., et al. 2005. Proc Natl Acad Sci U S A. 102: 11492-7. PMID: 16061792
3. p600, a unique protein required for membrane morphogenesis and cell survival.  |  Nakatani, Y., et al. 2005. Proc Natl Acad Sci U S A. 102: 15093-8. PMID: 16214886
4. Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.  |  Tasaki, T., et al. 2007. J Biol Chem. 282: 18510-18520. PMID: 17462990
5. Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway.  |  Lee, MJ., et al. 2008. Proc Natl Acad Sci U S A. 105: 100-5. PMID: 18162545
6. Protein 600 is a microtubule/endoplasmic reticulum-associated protein in CNS neurons.  |  Shim, SY., et al. 2008. J Neurosci. 28: 3604-14. PMID: 18385319

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ubr4 Antibody (21-Y) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Ubr4 Antibody (21-Y) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ubr4 Antibody (21-Y) Specifications

Alternate Product Name: Ubr4

Product Clone Name: 21-Y

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 94-191

Epitope Target: Ubr4

Epitope Species: human

Product Reactivity/Detection: Ubr4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Ubr4 Antibody (21-Y): N/A