Ubr3 Antibody (5A10): sc-517094
- Ubr3 Antibody (5A10) is a mouse monoclonal IgG1 κ Ubr3 antibody provided at 100 µg/ml
- raised against amino acids 1-110 representing partial length Ubr3 of human origin
- recommended for detection of Ubr3 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ubr3 Antibody (5A10). This work is in progress.
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Ubr3 Antibody (5A10) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Ubr3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Ubr3 antibody (5A10) is available as the non-conjugated format. Ubr3, also known as Ubiquitin-protein ligase E3-alpha-3 or Zinc finger protein 650, is a 1888 amino acid multi-pass membrane protein characterized by the presence of one UBR-type zinc finger and one RING-type zinc finger. Ubr3 plays a crucial role in the ubiquitin-proteasome system, particularly in the N-end rule pathway, where Ubr3 is involved in the recognition and degradation of proteins with destabilizing N-terminal residues. Unlike other family members, Ubr3 does not target these N-end rule substrates; instead, Ubr3 is believed to interact with small compounds that influence the degradation of its substrates. Studies show that adult mice lacking Ubr3 exhibit female-specific anosmia, indicating Ubr3′s regulatory role in sensory pathways such as olfaction. Ubr3 undergoes alternative splicing, resulting in four distinct isoforms, which may contribute to functional diversity and regulatory mechanisms within cellular processes.
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Ubr3 Antibody (5A10) References:
- A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. | Tasaki, T., et al. 2005. Mol Cell Biol. 25: 7120-36. PMID: 16055722
- E3 ubiquitin ligases. | Ardley, HC. and Robinson, PA. 2005. Essays Biochem. 41: 15-30. PMID: 16250895
- Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems. | Tasaki, T., et al. 2007. J Biol Chem. 282: 18510-18520. PMID: 17462990
- The mammalian N-end rule pathway: new insights into its components and physiological roles. | Tasaki, T. and Kwon, YT. 2007. Trends Biochem Sci. 32: 520-8. PMID: 17962019
- The substrate recognition domains of the N-end rule pathway. | Tasaki, T., et al. 2009. J Biol Chem. 284: 1884-95. PMID: 19008229
- The N-end rule pathway of protein degradation. | Varshavsky, A. 1997. Genes Cells. 2: 13-28. PMID: 9112437
- The mouse and human genes encoding the recognition component of the N-end rule pathway. | Kwon, YT., et al. 1998. Proc Natl Acad Sci U S A. 95: 7898-903. PMID: 9653112
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ubr3 Antibody (5A10) | sc-517094 | 100 µg/ml | $316.00 |