UBE2T Antibody (4E5): sc-100623

UBE2T Antibody (4E5) is a mouse monoclonal IgG2b kappa light chain antibody that detects the UBE2T protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-UBE2T antibody (4E5) is available as a non-conjugated format. UBE2T, also known as ubiquitin-conjugating enzyme E2 T, PIG50, or HSPC150, is a 197 amino acid protein that plays a pivotal role in the ubiquitination process, which is essential for regulating protein degradation within the cell. UBE2T is primarily located in the nucleus and cytoplasm, where UBE2T facilitates the attachment of ubiquitin to target proteins, marking them for degradation by the proteasome. Proper functioning of UBE2T is crucial, as UBE2T is involved in the Fanconi anemia pathway, a critical mechanism for DNA damage repair. Dysregulation of UBE2T can lead to the accumulation of damaged proteins and genomic instability, which are hallmarks of various diseases, including cancer. Using UBE2T (4E5) antibody in your research can provide valuable insights into the mechanisms of protein regulation and the implications of ubiquitination in cellular processes.

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UBE2T Antibody (4E5) References:

1. ATR couples FANCD2 monoubiquitination to the DNA-damage response.  |  Andreassen, PR., et al. 2004. Genes Dev. 18: 1958-63. PMID: 15314022
2. UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.  |  Machida, YJ., et al. 2006. Mol Cell. 23: 589-96. PMID: 16916645
3. Fanconi anemia and ubiquitination.  |  Zhang, Y., et al. 2007. J Genet Genomics. 34: 573-80. PMID: 17643942
4. UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination.  |  Alpi, A., et al. 2007. Mol Cell Biol. 27: 8421-30. PMID: 17938197
5. FANCD2 monoubiquitination provides a link between the HHR6 and FA-BRCA pathways.  |  Zhang, J., et al. 2008. Cell Cycle. 7: 407-13. PMID: 18277096

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-UBE2T Antibody (4E5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-UBE2T Antibody (4E5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

UBE2T Antibody (4E5) Specifications

Alternate Product Name: UBE2T

Product Clone Name: 4E5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-198

Epitope Target: UBE2T

Epitope Species: human

Product Reactivity/Detection: UBE2T

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for UBE2T Antibody (4E5): N/A