UBC9 Antibody (67AT1273.95.90): sc-130281

UBC9 Antibody (67AT1273.95.90) is a mouse monoclonal IgG1 antibody that detects UBC9 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). UBC9 plays a crucial role in the ubiquitin-mediated proteolytic pathway, which is essential for regulating protein degradation via the 26S proteasome, mediating endocytosis, and directing protein localization within the cell. UBC9 is primarily located in the nucleus, where UBC9 is involved in the modification of target proteins through a process known as sentrinization, which is vital for various cellular functions, including the regulation of gene expression and the cell cycle. UBC9 preferentially interacts with SUMO-1, a ubiquitin-like modifier, and UBC9 activity is critical for the proper functioning of transcription factors and mitotic regulators, such as E12, E47, RanBP2, and RanGAP1. The presence of a conserved cysteine residue in UBC9 is essential for the formation of thioester bonds with SUMO proteins, highlighting the importance of structural integrity in facilitating these post-translational modifications. Anti-UBC9 antibody (67AT1273.95.90) can help researchers gain valuable insights into the regulatory mechanisms of cellular processes, including cell cycle progression and differentiation, making UBC9 (67AT1273.95.90) antibody an indispensable tool for studies in molecular biology and biochemistry.

The preferred UBC9 antibody is UBC9 Antibody (C-12): sc-271057.