TYW5 Antibody (F-1): sc-390673
- TYW5 Antibody (F-1) is a mouse monoclonal IgG1 κ TYW5 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 7-36 of TYW5 of human origin
- TYW5 Antibody (F-1) is recommended for detection of TYW5 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TYW5 Antibody (F-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for TYW5 Antibody (F-1) for WB applications. This reagent is now offered in a bundle with TYW5 Antibody (F-1) (see ordering information below).
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TYW5 Antibody (F-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects TYW5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TYW5 Antibody (F-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TYW5 (F-1) antibody recognizes a protein that plays a crucial role in the biosynthesis of modified nucleosides, specifically in the formation of wybutosine, which is essential for proper tRNA functioning. This modification enhances the stability and efficiency of tRNA molecules during protein synthesis. TYW5 (F-1) monoclonal antibody targets a protein essential for maintaining cellular function, with potential implications in various diseases related to protein synthesis errors. Located on chromosome 2, the second largest human chromosome, TYW5 is associated with several genetic disorders, highlighting the significance of studying TYW5 protein in understanding complex genetic interactions and their effects on human health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TYW5 Antibody (F-1) References:
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. | Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
- Evidence for an ancestral alphoid domain on the long arm of human chromosome 2. | Avarello, R., et al. 1992. Hum Genet. 89: 247-9. PMID: 1587535
- ABCA12 is the major harlequin ichthyosis gene. | Thomas, AC., et al. 2006. J Invest Dermatol. 126: 2408-13. PMID: 16902423
- Regulation of intestinal cholesterol absorption. | Wang, DQ. 2007. Annu Rev Physiol. 69: 221-48. PMID: 17002594
- A two-carbon switch to sterol-induced autophagic death. | Tabas, I. 2007. Autophagy. 3: 38-41. PMID: 17172803
- Spectrum of ALMS1 variants and evaluation of genotype-phenotype correlations in Alström syndrome. | Marshall, JD., et al. 2007. Hum Mutat. 28: 1114-23. PMID: 17594715
- Compound heterozygous ABCA12 mutations including a novel nonsense mutation underlie harlequin ichthyosis. | Akiyama, M., et al. 2007. Dermatology. 215: 155-9. PMID: 17684380
- Alström syndrome. | Marshall, JD., et al. 2007. Eur J Hum Genet. 15: 1193-202. PMID: 17940554
- Origin of human chromosome 2: an ancestral telomere-telomere fusion. | IJdo, JW., et al. 1991. Proc Natl Acad Sci U S A. 88: 9051-5. PMID: 1924367
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TYW5 Antibody (F-1) | sc-390673 | 200 µg/ml | $316.00 | |||
TYW5 Antibody (F-1): m-IgG Fc BP-HRP Bundle | sc-526185 | 200 µg Ab; 10 µg BP | $354.00 | |||
TYW5 Antibody (F-1) AC | sc-390673 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TYW5 Antibody (F-1) HRP | sc-390673 HRP | 200 µg/ml | $316.00 | |||
TYW5 Antibody (F-1) FITC | sc-390673 FITC | 200 µg/ml | $330.00 | |||
TYW5 Antibody (F-1) PE | sc-390673 PE | 200 µg/ml | $343.00 | |||
TYW5 Antibody (F-1) Alexa Fluor® 488 | sc-390673 AF488 | 200 µg/ml | $357.00 | |||
TYW5 Antibody (F-1) Alexa Fluor® 546 | sc-390673 AF546 | 200 µg/ml | $357.00 | |||
TYW5 Antibody (F-1) Alexa Fluor® 594 | sc-390673 AF594 | 200 µg/ml | $357.00 | |||
TYW5 Antibody (F-1) Alexa Fluor® 647 | sc-390673 AF647 | 200 µg/ml | $357.00 | |||
TYW5 Antibody (F-1) Alexa Fluor® 680 | sc-390673 AF680 | 200 µg/ml | $357.00 | |||
TYW5 Antibody (F-1) Alexa Fluor® 790 | sc-390673 AF790 | 200 µg/ml | $357.00 | |||
TYW5 (F-1) Neutralizing Peptide | sc-390673 P | 100 µg/0.5 ml | $68.00 |