Type I 4-phosphatase Antibody (D-10): sc-390550
- Type I 4-phosphatase Antibody (D-10) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 1-120 mapping at the N-terminus of Type I 4-phosphatase of human origin
- recommended for detection of Type I 4-phosphatase of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and canine
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Type I 4-phosphatase Antibody (D-10) for WB applications. This reagent is now offered in a bundle with Type I 4-phosphatase Antibody (D-10) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Type I 4-phosphatase Antibody (D-10) is a mouse monoclonal IgG2b antibody that detects Type I 4-phosphatase in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Type I 4-phosphatase plays a crucial role in cellular signaling by hydrolyzing phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate, thereby regulating the levels of second messengers that are vital for various physiological processes. Type I 4-phosphatase is predominantly located in the cytoplasm and is alternatively spliced into two isoforms, α and β, which have been identified in human platelets, rat brain, heart, skeletal muscle, and spleen. A conserved motif, CKSAKDRT, within Type I 4-phosphatase structure, which includes the active site consensus sequence C-X5-R, underscores functional importance in signal transduction pathways. By acting as a signal-terminating enzyme, Type I 4-phosphatase helps regulate intracellular calcium levels, which is essential for maintaining cellular homeostasis and facilitating proper cellular responses to external stimuli. Anti-Type I 4-phosphatase antibody (D-10) serves as an invaluable tool for researchers exploring the intricate mechanisms of cellular signaling and the physiological implications of phosphoinositide metabolism.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Type I 4-phosphatase Antibody (D-10) | sc-390550 | 200 µg/ml | $316.00 | |||
Type I 4-phosphatase Antibody (D-10): m-IgGκ BP-HRP Bundle | sc-552164 | 200 µg Ab; 40 µg BP | $354.00 |