TXNDC4 Antibody (Y-19): sc-100600
- TXNDC4 Antibody (Y-19) is a mouse monoclonal IgG2b κ provided at 50 µg/0.5 ml
- raised against recombinant TXNDC4 of human origin
- recommended for detection of TXNDC4 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TXNDC4 Antibody (Y-19). This work is in progress.
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TXNDC4 Antibody (Y-19) is a mouse monoclonal IgG2b antibody that detects TXNDC4 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TXNDC4, also known as ERP44, is a 406 amino acid protein characterized by a single thioredoxin domain, which plays a crucial role in redox reactions within the cell. TXNDC4 is primarily localized in the lumen of the endoplasmic reticulum (ER), where TXNDC4 is essential for regulating oxidative protein folding and maintaining proper functioning of calcium channels by inhibiting inositol 1,4,5-triphosphate receptor type 1 (IP3R-I) activity. TXNDC4′s importance extends to retaining other proteins, such as Ero1-Lβ and Ero1-Lα, within the ER, contributing to the overall protein quality control system of the cell. TXNDC4 expression increases in response to ER stress, highlighting TXNDC4′s critical role in preserving intraluminal conditions and ensuring cellular homeostasis. An N-terminal ER targeting sequence and a C-terminal ER retention signal (RDEL) are vital for TXNDC4′s localization and function within the ER. With diverse applications and significant biological role, anti-TXNDC4 antibody (Y-19) serves as an invaluable tool for researchers studying ER stress and protein folding mechanisms in human cells.
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TXNDC4 Antibody (Y-19) References:
- ERp44 depletion exacerbates ER stress and aggravates diabetic nephropathy in db/db mice. | Pang, X., et al. 2018. Biochem Biophys Res Commun. 504: 921-926. PMID: 30224065
- The role of ERp44 in glucose and lipid metabolism. | Nyirimigabo, E., et al. 2019. Arch Biochem Biophys. 671: 175-184. PMID: 31283909
- The pivotal role of ERp44 in patrolling protein secretion. | Tempio, T. and Anelli, T. 2020. J Cell Sci. 133: PMID: 33173013
- Exosomal ERp44 derived from ER-stressed cells strengthens cisplatin resistance of nasopharyngeal carcinoma. | Xia, T., et al. 2021. BMC Cancer. 21: 1003. PMID: 34493236
- Ero1α-Dependent ERp44 Dissociation From RyR2 Contributes to Cardiac Arrhythmia. | Hamilton, S., et al. 2022. Circ Res. 130: 711-724. PMID: 35086342
- ERp44 is required for endocardial cushion development by regulating VEGFA secretion in myocardium. | Bi, Y., et al. 2022. Cell Prolif. 55: e13179. PMID: 35088919
- Inhibitors of ERp44, PDIA1, and AGR2 induce disulfide-mediated oligomerization of Death Receptors 4 and 5 and cancer cell death. | Law, ME., et al. 2022. Cancer Lett. 534: 215604. PMID: 35247515
- ERp44 Regulates the Proliferation, Migration, Invasion, and Apoptosis of Gastric Cancer Cells Via Activation of ER Stress. | Tian, Y., et al. 2023. Biochem Genet. 61: 809-822. PMID: 36178559
- SUMOylation of ERp44 enhances Ero1α ER retention contributing to the pathogenesis of obesity and insulin resistance. | Xie, H., et al. 2023. Metabolism. 139: 155351. PMID: 36427672
- ERP44 could serve as a bridge mediating prognosis and immunity for glioma via single-cell and bulk RNA-sequencing. | Ji, X., et al. 2025. Gene. 933: 148963. PMID: 39341519
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TXNDC4 Antibody (Y-19) | sc-100600 | 50 µg/0.5 ml | $333.00 |