TWIK-1 Antibody (4D7): sc-517040

TWIK-1 Antibody (4D7) is a mouse monoclonal IgG1 kappa light chain antibody that detects TWIK-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-TWIK-1 antibody (4D7) is available as a non-conjugated format. TWIK-1, a member of the two-pore domain potassium channel family, plays a crucial role in maintaining resting membrane potential and regulating cellular excitability, vital for proper neuronal function and overall cellular homeostasis. TWIK-1 is predominantly expressed in the brain, where TWIK-1 contributes to neuronal activity modulation, but also appears at lower levels in lung, kidney, and skeletal muscle. TWIK-1′s unique structure, characterized by four transmembrane segments, forms a functional channel that selectively permits potassium ions to flow across cell membranes, influencing various physiological processes. TWIK-1 interacts with other potassium channels, such as TASK and TREK, which can further modulate activity and impact cellular responses to various stimuli. TWIK-1′s ability to respond to changes in cellular environment underscores importance in both health and disease, making TWIK-1 a valuable target for research in neurobiology and related fields.

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TWIK-1 Antibody (4D7) References:

1. TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family.  |  Chavez, RA., et al. 1999. J Biol Chem. 274: 7887-92. PMID: 10075682
2. Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit.  |  Pountney, DJ., et al. 1999. FEBS Lett. 450: 191-6. PMID: 10359073
3. TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.  |  Lesage, F., et al. 1996. EMBO J. 15: 1004-11. PMID: 8605869
4. Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.  |  Fink, M., et al. 1996. EMBO J. 15: 6854-62. PMID: 9003761
5. The structure, function and distribution of the mouse TWIK-1 K+ channel.  |  Lesage, F., et al. 1997. FEBS Lett. 402: 28-32. PMID: 9013852
6. TASK, a human background K+ channel to sense external pH variations near physiological pH.  |  Duprat, F., et al. 1997. EMBO J. 16: 5464-71. PMID: 9312005
7. TRAAK is a mammalian neuronal mechano-gated K+ channel.  |  Maingret, F., et al. 1999. J Biol Chem. 274: 1381-7. PMID: 9880510

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TWIK-1 Antibody (4D7) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-TWIK-1 Antibody (4D7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TWIK-1 Antibody (4D7) Specifications

Alternate Product Name: TWIK-1

Product Clone Name: 4D7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 265-336

Epitope Target: TWIK-1

Epitope Species: human

Product Reactivity/Detection: TWIK-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for TWIK-1 Antibody (4D7): N/A